Time course of changes in adenosine 5′-monophosphate airway responsiveness with inhaled heparin in allergic asthma☆, ☆☆, ★

Heparin attenuates symptoms and mast cell degranulation induced by AMP nasal provocation

“…23 In our current study, the unfractionated heparin was used mainly because we have shown previously that inhaled unfractionated heparin attenuated the airway response to AMP bronchial provocation. 9 The mechanism by which heparin attenuates the nasal response to AMP and allergen is unclear and requires additional studies. In asthma, inhaled heparin seems to exert a preferential protective effect against stimuli such as allergen, 7 exercise, 8 and AMP 9 that are known to cause bronchoconstriction mainly by releasing spasmogenic mediators from airway mast cells.…”

“…The dosage of heparin used in this investigation and the timing of administration before challenge were chosen on the basis of previous studies that have been shown to reduce the bronchospastic response to AMP effectively in subjects with asthma. 9 Treatment solutions were freshly prepared on each visit by a technician who was blind to the study rationale and were aerosolized from a nebulizer (DeVilbiss 646; Somerset, Pa) connected to a nasal adaptor.…”

“…5,6 In experimental models of clinical asthma, it has been reported that heparin given by inhalation inhibits the bronchoconstrictor response to a variety of stimuli, including allergen, 7 exercise, 8 and adenosine. 9 The mechanism of action for this protective effect of heparin is not known. Page 10 has speculated that the inhibitory effect of inhaled heparin in the asthmatic airways may be a result of its suppressive action on mast cell degranulation.…”

Review - Heparin and Related Molecules as a New Treatment for Asthma

“…42 Conpounds have been shown to modulate inflammatory versely, in other studies in asthmatics, a similar dose airway responses. In rabbits, UFH and a LMW hepof UFH inhaled at different time-intervals before arinoid (Org 10172) have been shown to reduce platelet the challenge, failed to protect against methacholineactivating factor (PAF)-induced airway inflammation induced bronchoconstriction 43,44 and metabisulphiteand hyperresponsiveness. 32 Similarly, PAF-induced airway eosinophilia was inhibited in guinea-pigs.…”

“…33 induced airway responsiveness, 44 whereas increased the PC 20 to adenosine 5′-monophosphate (AMP). 43 In may provide a novel approach to the treatment of allergic airway diseases. exercise-induced asthma, pretreatment with UFH at a dose of 1000 U/kg inhaled at several time-intervals before challenge, almost completely blocked the exercise-induced bronchoconstriction.…”