2019
DOI: 10.1016/j.pharep.2019.02.013
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Time course of cardiomyopathy induced by doxorubicin in rats

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Cited by 16 publications
(17 citation statements)
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“…R. glutinosa also displays antiaging properties by exerting protective effects on the cardiovascular and vascular systems. Catalpol, an iridoid glycoside isolated from the roots of R. glutinosa, has been reported to display neuroprotective effects (38,39). Previous studies have also demonstrated the cardioprotective and anti-inflammatory properties of catalpol, including apoptosis inhibition, reduced neuronal death and promotion of differentiation (40,41).…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…R. glutinosa also displays antiaging properties by exerting protective effects on the cardiovascular and vascular systems. Catalpol, an iridoid glycoside isolated from the roots of R. glutinosa, has been reported to display neuroprotective effects (38,39). Previous studies have also demonstrated the cardioprotective and anti-inflammatory properties of catalpol, including apoptosis inhibition, reduced neuronal death and promotion of differentiation (40,41).…”
Section: Discussionmentioning
confidence: 99%
“…Therefore, DOX induces cardiomyocyte damage when it destroys tumor cells ( 4 ). Early myocardial damage manifests as myocarditis and arrhythmia; however, when DOX reaches a specific dose, irreversible myocardial expansion occurs, which may eventually develop into heart failure ( 38 ). Although numerous efforts have been made to reduce the toxicity of DOX, no significant progress in the prevention and treatment of DOX-induced toxicity has been reported.…”
Section: Discussionmentioning
confidence: 99%
“…Other short-term models use 2–3.4 mg/kg of DOX every other day, six times intraperitoneally (the total dose is 12–20 mg/kg) ( Zbinden et al, 1978 ; Lanza et al, 1989 ; Carvalho et al, 2010 ; Razmaraii et al, 2016 ; Cappetta et al, 2018 ; Aygun and Gul, 2019 ; Barış et al, 2019 ). Long-term rat models typically use 1–5 mg/kg every week for 2–12 weeks with a cumulative dose of 3–25 mg/kg ( Villani et al, 1991 ; Sacco et al, 2001 ; Sayed-Ahmed et al, 2001 ; Rahimi Balaei et al, 2010 ; Hydock et al, 2012 ; Hole et al, 2013 ; Toblli et al, 2014 ; Kang et al, 2017 ; Medeiros-Lima et al, 2019 ; Wang et al, 2019 ; Chakouri et al, 2020 ; Sharma et al, 2020 ). Thus, a short-term high-dose injection model would be suitable for assessing acute cardiotoxicity, while a long-term low-dose model would be suitable for assessing chronic cardiotoxicity.…”
Section: Anthracycline Cardiomyopathy Modelsmentioning
confidence: 99%
“…Histological examination showed that this injection protocol results in irregularly spaced myocardial fibers with inflammation, edema, and leukocyte cell infiltration. Other models use 1 mg/kg of DOX for 10 days and 1.25 mg/kg of DOX 4 times a week for 4 weeks ( Medeiros-Lima et al, 2019 ; Aykan et al, 2020 ). The results show that DOX significantly reduced body, heart and left ventricular weight one week after stopping DOX.…”
Section: Anthracycline Cardiomyopathy Modelsmentioning
confidence: 99%
“…Irrespective of its cause, cardiomyocyte injury by itself triggers an inflammatory reaction, which also induces fibroblast activation [6][7][8][9].. In anthracycline-induced cardiomyopathy, both inflammatory and adverse ECM remodeling processes are present [4,[10][11][12][13][14]. Several transcriptomic analysis in animal and in vitro studies have reported differential expression in genes related to the innate immune system, TGFß signaling, and collagen turnover [10,[15][16][17][18].…”
Section: Introductionmentioning
confidence: 99%