Time course of bronchoconstrictive response in asthmatic subjects to reduced temperature.

Ramsey, James M.

doi:10.1136/thx.32.1.26

Cited by 12 publications

(8 citation statements)

References 12 publications

(13 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The final model included effects at lags 1 and 2, that is, delayed effects from up to 2 d prior to the day on which the consultation occurred. Sudden changes in temperature have been implicated in the laboratory setting in the onset of asthma symptoms (Ramsey 1977, Strauss et al 1978, O'Byrne et al 1982, Zawadski et al 1988) but no such effect was a significant predictor in our model. Given the anticipated small overall effect size for the daily weather, there was limited power to detect inter-actions.…”

Section: Discussioncontrasting

confidence: 37%

A model of the relationship between consultation behaviour for asthma in a general practice and the weather

Kljakovic¹,

Salmond²

1998

Clim. Res.

View full text Add to dashboard Cite

The aim of this study was to build a model showing the relationship between consultations for asthma and the daily weather in a suburban computerised general practice in New Zealand. A retrospective count of the number of asthmatic patients attending the practice on any particular day for a consultation for asthma was compared with the weather variables temperature, rainfall, relative humidity, and wind strength. Quasi-likelihood Poisson regression models were built in steps. There were 3844 consultations for asthma between October 1, 1986 and October 30, 1991. The number varied from 0 to 11 consultations per day (mean 2.1). The annual means were 1.3, 1.9, 2.3, 2.5, and 2.7 consultations per day, respectively. After variables indicating time trends, days of the week, and holiday periods were included in the model, temperature and relative humidity provided the only significant additional explanatory power for variation in consultations.

show abstract

Section: Discussioncontrasting

confidence: 37%

A model of the relationship between consultation behaviour for asthma in a general practice and the weather

Kljakovic¹,

Salmond²

1998

Clim. Res.

View full text Add to dashboard Cite

show abstract

“…Cooling of the face'7 and body18 19 have also been reported to produce bronchoconstriction, persisting for up to 15 minutes after return to normal temperature. 19 Another possibility is non-immunologically provoked mediator release, similar to that seen with cold induced urticaria.20 The timing of the response could suggest production of membrane derived mediators such as platelet activating factor or leukotrienes, both of which have been associated with increased bronchial responsiveness.2' 22 The subjects selected for this study all originated from the Indian subcontinent. The reason for this selection was to obtain a sample of patients with a high yield of positive responses to the oral challenges.…”

Section: Discussionmentioning

confidence: 99%

Role of the oesophagus in asthma induced by the ingestion of ice and acid.

Wilson

Chudry

Silverman

1987

Thorax

View full text Add to dashboard Cite

Twelve Asian patients with a history of asthma exacerbated by ingestion of ice and acidic drinks were selected for study. To determine the site of response to ingested ice and acid they were challenged with ice or dilute hydrochloric acid, which was orally retained on one day and swallowed on another. On a third day a placebo was given. The airway response was assessed by measuring FEV, and the provocative concentration of histamine that reduced the FEV1 by at least 20% (PC20). There was no significant change in FEV1 or histamine PC20 after placebo or the orally retained challenges for the group as a whole or for any individual. After the ice and hydrochloric acid had been swallowed there was a small but statistically significant mean fall in FEV,, increasing to a maximum 90 minutes after ingestion, together with a significant increase in bronchial responsiveness. As conditioning of the inspired air would have been similar after orally retained and after swallowed ice or acid, the response is likely to be due to oesophageal stimulation. The mechanism of the response to oesophageal stimulation is unclear, but the slow time course seems to preclude a simple neural reflex.Ingestion of ice' and of dilute hydrochloric acid2 have both been shown to increase bronchial responsiveness in some asthmatic individuals. As soft drinks (pH about 3) are frequently served iced this could be a potential hazard for many individuals with asthma, particularly children.The mechanism of this response is unclear but is likely to be due to stimulation of the upper gastrointestinal tract, although conditioning of the inspired air is a possibility. The

show abstract

“…This may have both direct and indirect effects on the asthmatic. First, the cold air itself has been shown to induce asthma (1)(2)(3), and this may directly increase admissions to hospitals when this air mass occurs. Second, the typical behavioral response to such an event is for individuals to turn on an indoor heating system which has been dormant and collecting allergens since the previous spring, sending large quantities of dust, mites, mold spores, and other materials into a sealed environment (7).…”

Section: Discussionmentioning

confidence: 99%

“…Weather has a dual role, affecting the asthmatic through direct and indirect means. Among direct influences are rapid meteorological fluctuation, such as the onset of cold weather in the fall, which appears to be associated with decreased lung function in asthmatics (1)(2)(3). Increased visits to New York City emergency rooms were found to be associated with decreases in temperature, especially during and after the first and second onset of cold periods in the fall; another study incorporating a subjective identification of weather events found nearly all asthma epidemics in both New Orleans and New York City were preceded by the passage of a cold front followed by a high pressure system (4)(5)(6)(7).…”

mentioning

confidence: 99%

A Synoptic Evaluation of Asthma Hospital Admissions in New York City

Jamason

Kalkstein

Gergen

1997

Am J Respir Crit Care Med

View full text Add to dashboard Cite

An evaluation of weather/asthma relationships in the New York City Standard Metropolitan Statistical Area (SMSA) is developed using a synoptic climatological methodology. This procedure isolates "air masses," or bodies of air that are homogeneous in meteorological character, and relates them to daily counts of overnight asthma hospital admissions. The synoptic procedure used here, known as the temporal synoptic index (TSI), can identify air masses in automated fashion for every day over many years. It is apparent that certain air masses are related to statistically significant increases in asthma hospital admissions. The impact varies seasonally, with weather having a particularly important impact on asthma admissions during fall and winter. It appears that air pollution has little impact on asthma during these two seasons, and the air masses associated with the highest admissions are not distinguished by high concentrations of pollutants. However, during spring and summer, the air masses associated with highest admissions are among those with high pollution concentrations. There is a strong interseasonal differential response to weather and air pollution by asthmatics in New York City. If these results can be replicated at other locations in future studies, it may be possible to develop an asthma/weather watch-warning system, based on the expected arrival of high-admissions air masses.

show abstract

Time course of bronchoconstrictive response in asthmatic subjects to reduced temperature.

Cited by 12 publications

References 12 publications

A model of the relationship between consultation behaviour for asthma in a general practice and the weather

A model of the relationship between consultation behaviour for asthma in a general practice and the weather

Role of the oesophagus in asthma induced by the ingestion of ice and acid.

A Synoptic Evaluation of Asthma Hospital Admissions in New York City

Contact Info

Product

Resources

About