Time course for the recovery of physical performance, blood hemoglobin, and ferritin content after blood donation

Ziegler, Andreas Kraag; Grand, Johannes; Stangerup, Ida; Nielsen, Hans Jørgen; Dela, Flemming; Magnussen, Karin; Helge, Jørn Wulff

doi:10.1111/trf.12926

Cited by 29 publications

(42 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Despite these methodologic differences all of these studies found that a reduction in blood Hb (B‐Hb) impairs physical performance . Extending the findings by Burnley and colleagues and Judd and colleagues we observed that peak VO 2 and time trial (TT) performance were back to baseline 2 weeks after a standard blood donation of 450 mL of blood, whereas B‐Hb concentration was only returned to baseline after 4 weeks …”

supporting

confidence: 64%

Temporary impact of blood donation on physical performance and hematologic variables in women

et al. 2017

Self Cite

View full text Add to dashboard Cite

show abstract

supporting

confidence: 64%

Temporary impact of blood donation on physical performance and hematologic variables in women

et al. 2017

Self Cite

View full text Add to dashboard Cite

show abstract

“…Hematocrit, hemoglobin concentration, hemoglobin mass, ferritin, iron, and RBC were all reduced after blood donation and their values were still lower than basal values after 4 weeks, except for iron and hemoglobin mass. We hereby confirm previous reports showing that recovery of hematological parameters may take a few weeks or even more [15–17]. Here, hematocrit, hemoglobin concentration, ferritin, and RBC were still lower 3 months after the first blood donation, at the time of beginning the second test series, indicating that the recovery of those parameters was incomplete before the next blood donation.…”

Section: Discussionsupporting

confidence: 90%

“…The largest reduction in maximal power output was 4% and in VO 2 peak 11%, which corresponds to values previously reported [15, 20, 22, 24]. Only one study extended the recovery period until 4 weeks [15].…”

Section: Discussionsupporting

confidence: 84%

“…After donating one unit of whole blood, hematological parameters decrease immediately [13–15]. Blood withdrawal causes a reduction of plasma volume which is almost completely restored 24–48 h after donation [14].…”

Section: Introductionmentioning

confidence: 99%

“…Blood withdrawal causes a reduction of plasma volume which is almost completely restored 24–48 h after donation [14]. Recovery of hematocrit, ferritin, and hemoglobin concentrations takes more time as those parameters have been found to be reduced beyond 4 weeks after donation [15], which corresponds approximately to the period needed for total hemoglobin mass to return to baseline levels [16]. Of note, serum ferritin concentration decreases further when donations are repeated [17].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Effect of Repeated Whole Blood Donations on Aerobic Capacity and Hemoglobin Mass in Moderately Trained Male Subjects: A Randomized Controlled Trial

et al. 2016

View full text Add to dashboard Cite

BackgroundThe aims of the present study were to investigate the impact of three whole blood donations on endurance capacity and hematological parameters and to determine the duration to fully recover initial endurance capacity and hematological parameters after each donation.MethodsTwenty-four moderately trained subjects were randomly divided in a donation (n = 16) and a placebo (n = 8) group. Each of the three donations was interspersed by 3 months, and the recovery of endurance capacity and hematological parameters was monitored up to 1 month after donation.ResultsMaximal power output, peak oxygen consumption, and hemoglobin mass decreased (p < 0.001) up to 4 weeks after a single blood donation with a maximal decrease of 4, 10, and 7%, respectively. Hematocrit, hemoglobin concentration, ferritin, and red blood cell count (RBC), all key hematological parameters for oxygen transport, were lowered by a single donation (p < 0.001) and cumulatively further affected by the repetition of the donations (p < 0.001). The maximal decrease after a blood donation was 11% for hematocrit, 10% for hemoglobin concentration, 50% for ferritin, and 12% for RBC (p < 0.001). Maximal power output cumulatively increased in the placebo group as the maximal exercise tests were repeated (p < 0.001), which indicates positive training adaptations. This increase in maximal power output over the whole duration of the study was not observed in the donation group.ConclusionsMaximal, but not submaximal, endurance capacity was altered after blood donation in moderately trained people and the expected increase in capacity after multiple maximal exercise tests was not present when repeating whole blood donations.Electronic supplementary materialThe online version of this article (doi:10.1186/s40798-016-0067-7) contains supplementary material, which is available to authorized users.

show abstract

On the trail of blood doping—microRNA fingerprints to monitor autologous blood transfusions in vivo

Mussack

Wittmann²,

Pfaffl

2021

American J Hematol

View full text Add to dashboard Cite

Autologous blood doping refers to the illegal re‐transfusion of any quantities of blood or blood components with blood donor and recipient being the same person. The re‐transfusion of stored erythrocyte concentrates is particularly attractive to high‐performance athletes as this practice improves their oxygen capacity excessively. However, there is still no reliable detection method available. Analyzing circulating microRNA profiles of human subjects that underwent monitored autologous blood transfusions seems to be a highly promising approach to develop novel biomarkers for autologous blood doping. In this exploratory study, we randomly divided 30 healthy males into two different treatment groups and one control group and sampled whole blood at several time points at baseline, after whole blood donation and after transfusion of erythrocyte concentrates. Hematological variables were recorded and analyzed following the adaptive model of the Athlete Biological Passport. microRNA profiles were examined by small RNA sequencing and comprehensive multivariate data analyses, revealing microRNA fingerprints that reflect the sampling time point and transfusion volume. Neither individual microRNAs nor a signature of transfusion‐dependent microRNAs reached superior sensitivity at 100% specificity compared to the Athlete Biological Passport (≤11% 6 h after transfusion versus ≤44% 2 days after transfusion). However, the window of autologous blood doping detection was different. Due to the heterogenous nature of doping, with athletes frequently combining multiple medications in order to both gain a competitive advantage and interfere with known testing methods, the true applicability of the molecular signature remains to be validated in real anti‐doping testings.

show abstract

Time course for the recovery of physical performance, blood hemoglobin, and ferritin content after blood donation

Abstract: The individual recovery was variable, but physical performance was recovered 14 days after a standard blood donation, despite blood Hb concentration remaining lower than at baseline.

Cited by 29 publications

References 27 publications

Temporary impact of blood donation on physical performance and hematologic variables in women

Temporary impact of blood donation on physical performance and hematologic variables in women

Effect of Repeated Whole Blood Donations on Aerobic Capacity and Hemoglobin Mass in Moderately Trained Male Subjects: A Randomized Controlled Trial

On the trail of blood doping—microRNA fingerprints to monitor autologous blood transfusions in vivo

Contact Info

Product

Resources

About