Time Course for Effects of Sulpiride and Chlorpromazine on Monoamine Metabolite and Prolactin Levels in Cerebrospinal Fluid from Schizophrenic Patients

Härnryd, C; Bjerkenstedt, Lars; Gullberg, Bo; Oxenstierna, Gabriel; Sedvall, Göran; Wiesel, Frits‐Axel

doi:10.1111/j.1600-0447.1984.tb06860.x

Cited by 71 publications

(26 citation statements)

References 34 publications

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“…The duration of increased prolactin concentrations from baseline levels has also been reported to be shorter for remoxipride than for sulpiride [7]. The trough levels of prolactin were markedly increased following repeated administrations of sulpiride in psychiatric patients [43]. During treatment with remoxipride the trough prolactin levels were not increased or only mildly or moderately increased [8][9][10][11].…”

Section: Discussionmentioning

confidence: 99%

Influence of the dosing interval on prolactin release after remoxipride.

Movin-Osswald¹,

Hammarlund‐Udenaes²,

Bahr³

et al. 1995

Brit J Clinical Pharma

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1 The prolactin response following administration of the D2-dopamine receptor antagonist remoxipride was studied in eight healthy male volunteers. correspond to a maximal release of prolactin according to earlier studies. A small second peak of prolactin was observed after 2 h. The release was gradually increased with longer time intervals between the consecutive doses. The refractory period for a second prolactin release similar to the first one after remoxipride was found to be 24 h for most of the subjects. 3 TRH resulted in a faster and higher increase in prolactin response of a shorter duration than after remoxipride administered 2 h after the first dose.

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Section: Discussionmentioning

confidence: 99%

Influence of the dosing interval on prolactin release after remoxipride.

Movin-Osswald¹,

Hammarlund‐Udenaes²,

Bahr³

et al. 1995

Brit J Clinical Pharma

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“…Amisulpride has a low propensity to induce extrapyramidal symptoms, characterizing the drug as an atypical antipsychotic. However, on the basis of its higher potential to induce elevations of prolactin levels, the drug resembles more than any other atypical drug the side effect profile of typical antipsychotic agents [1,2].…”

Section: Introductionmentioning

confidence: 99%

“…The influence of antipsychotics on prolactin is related to a number of known side effects such as alterations of the menstrual cycle, amenorrhea with and without galactorrhea, gynecomastia, decreased libido, and impotence. Differential effects of various antipsychotics on serum prolactin levels have been reported [1,2]. Recently, the endocrine actions of two antipsychotics with different receptor affinity profiles and pharmacokinetic properties were compared.…”

Section: Introductionmentioning

confidence: 99%

Long-Term Effects of the Substituted Benzamide Derivative Amisulpride on Baseline and Stimulated Prolactin Levels

Schlößer¹,

Gründer²,

Anghelescu³

et al. 2002

Neuropsychobiology

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In the present study, we investigated the long-term effects of treatment with amisulpride, a substituted benzamide derivative, as compared with the effects of treatment with flupenthixol, a thioxanthene, on the prolactin levels in schizophrenic patients. After completing 6 weeks of medication with either amisulpride or flupenthixol, the patients entered a long-term maintenance treatment with amisulpride 200–600 mg/day or flupenthixol 5–15 mg/day for a maximum of 12 months with a subsequent drug-free follow-up until month 15. Eighteen initially included patients were still participating in the study at month 6. In the flupenthixol group, only 1 patient treated reached month 12, and none of the patients reached month 15. For the amisulpride treatment group, months 12 and 15 were completed by 9 and 6 patients, respectively. After 1, 3, 6, and 12 months of treatment, and finally 3 months after cessation of treatment, the basal and thyrotropin-releasing hormone-stimulated secretions of prolactin were investigated. The prolactin plasma levels were elevated in both treatment groups during the course of maintenance treatment with a maximum effect at month 1. Flupenthixol treatment initially raised the prolactin levels about two- or threefold, and a subsequent decline during months 3 and 6 occurred. However, only the changes for month 1 reached the level of a statistical trend. The prolactin secretion was initially increased over tenfold by amisulpride. The prolactin levels at months 1, 3, 6, and 12 were significantly elevated as compared with the baseline values. A continuous decline of prolactin levels in both treatment groups occurred over the course of the next months. The prolactin response after the thyrotropin-releasing hormone challenge was not significantly changed over the long-term course. Notably, in the amisulpride group, 3 months after cessation of treatment at month 12, the elevated levels of prolactin returned to baseline at month 15. In summary, amisulpride demonstrated more pronounced effects than flupenthixol on the prolactin levels. However, the findings indicate also that treatment with amisulpride at clinically effective doses can be achieved at significantly lower prolactin levels during the long-term maintenance phase than during the prior acute phase.

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“…Moving beyond common receptor types, however, substituted benzamides interact with the g-hydroxybutyrate (GHB) receptor (Ratomponirina 1998), which may have a bearing on sedative actions. Sulpiride also produces higher prolactin levels than other, broaderspectrum antipsychotics (Mannisto 1978;Harnryd 1984), something clinicians have long been aware of in increased rates of galactorrhoea. Extrapyramidal side-effects may not be the only non-target actions open to amelioration by broad receptor interactions, and brisk prolactin response may be the price that comes with high D 2 selectivity.…”

Section: Sulpiride (Table 3)mentioning

confidence: 99%

Meet the relatives: a reintroduction to the clinical pharmacology of ‘typical’ antipsychotics (Part 2)

Owens

2012

Adv. psychiatr. treat

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SummaryThis second of two articles on the ‘typical’ (‘first-generation’) antipsychotics covers non-phenothiazines: thioxanthenes (flupentixol and zuclopenthixol), butyrophenones/diphenylbutylpiperidines (including one-time world market-leader haloperidol, and pimozide) and sulpiride, for many years the only substituted benzamide available in the UK. Several tolerability issues ascribed specifically or more frequently to older antipsychotics are also discussed.

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Time Course for Effects of Sulpiride and Chlorpromazine on Monoamine Metabolite and Prolactin Levels in Cerebrospinal Fluid from Schizophrenic Patients

Cited by 71 publications

References 34 publications

Influence of the dosing interval on prolactin release after remoxipride.

Influence of the dosing interval on prolactin release after remoxipride.

Long-Term Effects of the Substituted Benzamide Derivative Amisulpride on Baseline and Stimulated Prolactin Levels

Meet the relatives: a reintroduction to the clinical pharmacology of ‘typical’ antipsychotics (Part 2)

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