Time Course and Morphology of Vascular Effects Associated with Photodynamic Therapy

Comparison of SD-Optical Coherence Tomography Angiography and Indocyanine Green Angiography in Type 1 and 2 Neovascular Age-related Macular Degeneration

“…30 This learning has already been introduced in the preceding era of photodynamic therapy where the neovascular lesion ''disappeared'' by conventional FA standards, but was clearly found to persist by ICGA and refilled quickly during follow-up. 31 Despite the intriguing option to visualize and measure lesion size by OCTA with all its presumed details, this strict ICGA comparison reveals the deficiency of OCTA-based quantitative CNV monitoring. Rather than SD-OCTA resolution of the lesion, a slowing of perfusion speeds most probably contributes to a smaller appearance.…”

Myeloid progenitors differentiate into microglia and promote vascular repair in a model of ischemic retinopathy

“…Laser photocoagulation has been used to destroy ischemic retinal tissue with the idea of causing the regression of neovascularization as the ischemic drive is decreased. More recently, advances in the field of angiogenesis have led to the development of many antiangiogenic compounds such as VEGF inhibitors, angiostatic steroids, integrin antagonists, and others (3)(4)(5)(6)(7). While alignment of supply and demand through laser ablation of ischemic retina is efficacious in certain subgroups of ischemic retinopathies, this approach and the use of angiostatic compounds often fail to completely inhibit abnormal vascular growth and are associated with a large degree of tissue injury and the risk of local, as well as systemic, complications (8).…”

Low-fluence-rate photodynamic therapy to treat subfoveal choroidal neovascularization in pathological myopia. A study of efficacy and safety

“…Mean post-operative follow-up was 13.4±2.46 months (range: [12][13][14][15][16][17][18][19][20][21]. The mean number of treatments was 1.37± 0.66 (range: 1-3).…”

“…Comparing LFPDT and SFPDT for AMD-CNV, Michels et al showed that by reducing the fluence rate it is possible to obtain the same closure rate of CNV with less secondary effects on the physiologic choroidal vasculature and definitively less damage to RPE-choriocapillaris complex, [11] possibly because LFPDT spared the vessel endothelium and caused less inflammation [20].…”