Time-averaged hemoglobin values, not hemoglobin cycling, have an impact on outcomes in pediatric dialysis patients

Bakkaloğlu, Sevcan A.; Kandur, Yaşar; Serdaroğlu, Erkin; Noyan, Aytül; Bayazıt, Aysun Karabay; Taşdemir, Mehmet; Özlü, Sare Gülfem; Özçelik, Gül; Dursun, İsmail; Alparslan, Caner; Akçaboy, Meltem; Atikel, Yeşim Özdemir; Parmaksız, Gönül; Atmış, Bahriye; Sever, Lale

doi:10.1007/s00467-018-4013-4

Cited by 4 publications

(3 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The blood pressure index was calculated as the ratio of mean blood pressure values from the follow-ups for 1 year in outpatient clinic to the value of the 95th percentile by age, sex, and height [15]. Peritoneal glucose exposure was calculated according to dialysate volume and dialysate glucose concentration (daily amount of glucose exposure was defined as g/m 2 ), and total annual exposure was calculated as (dialysate volume [L] × dialysate glucose concentration [g/L] × day) [16].…”

Section: Methodsmentioning

confidence: 99%

Erythropoietin Resistance Index and the Affecting Factors in Children with Peritoneal Dialysis

et al. 2021

View full text Add to dashboard Cite

Background: Erythropoiesis-stimulating agents (ESAs) are used to treat anemia in CKD. Erythropoietin resistance index (ERI) is a useful tool used to evaluate the response to ESAs. In this study, we aimed to evaluate the causes of high ERI in children undergoing peritoneal dialysis (PD). Method: Patients who had been on PD for at least 1 year were included in this retrospective study. Demographic characteristics, residual kidney function (RKF), adequacy of dialysis, peritoneal glucose exposure, the number and reason for hospitalization, and medications were recorded. Anemia and laboratory parameters that may affect anemia were noted by taking the average of laboratory values in the last follow-up year (time-averaged). The weekly ESA dose was proportioned to the annual average hemoglobin value and body weight to calculate the ERI in terms of U/kg/week/g/dL. Results: A total of 100 patients were included in the study. The mean ESA dose and ERI value were 119.8 ± 66.22 U/kg/week and 13.01 ± 7.52 U/kg/week/g/dL, respectively. It was determined that the patients <5 years of age have very high ERI value, and these patients need 2 times more ESA than those >10 years of age. Absence of RKF, large number of hospitalization, and ACEI use were also found to affect the ERI value negatively. Conclusion: We demonstrate that the most important factor affecting ERI value is young age. We also reveal that absence of RKF, large number of hospitalization, and ACEI use are also important variables affecting the ERI value.

show abstract

Section: Methodsmentioning

confidence: 99%

Erythropoietin Resistance Index and the Affecting Factors in Children with Peritoneal Dialysis

et al. 2021

View full text Add to dashboard Cite

show abstract

“…12,14,15 Sedangkan kelangsungan hidup pasien HD dipengaruhi oleh banyak indikator terutama anemia, infeksi, adekuasi HD, nutrisi dan penyakit kardiovaskuler. 12,16 Beberapa studi telah menilai hubungan antar parameter ginjal seperti hubungan antara anemia dengan survival pasien HD, dimana anemia dihubungkan dengan peningkatan resiko kematian pasien HD [16][17][18] . Studi-studi tersebut menunjukkan bahwa peningkatan resiko kematian dihubungkan dengan peningkatan kejadian kardiovaskular akibat dari hipertrofi ventrikel kiri dan iskemik otot jantung.…”

Section: Pendahuluanunclassified

“…13,[19][20][21][22][23] Walau nilai cut off dan waktu pemeriksaan hemoglobin (Hb) masih bervariasi antar studi, beberapa studi menyebutkan nilai Hb > 10 g/dl dapat mengurangi resiko kematian pada pasien PGK yang menjalani HD dengan perubahan Hb dan Hb setelah HD merupakan indikator Hb terbaik yang dihubungkan dengan peningkatan angka kematian 1 tahun pasien HD. 16,20 Meskipun beberapa studi di luar negeri telah menilai hubungan antar parameter pada proses dan outcome HD seperti yang telah dijelaskan sebelumnya, studi konfrehensif yang mencari hubungan antara indikator proses HD seperti Hb, adekuasi, tingkat malfungsi dan infeksi akses vaskular dengan parameter outcome HD seperti kualitas hidup dan fungsi kardiak belum pernah dilakukan di Indonesia. Oleh karena itu, penelitian ini bertujuan untuk menilai hubungan antara indicator proses HD dengan kualitas hidup dan kinerja jantung pasien PGK yang menjalani HD di Provinsi Aceh.…”

Section: Pendahuluanunclassified

Hemoglobin dan Adekuasi Berkorelasi dengan Kualitas Hidup dan Kinerja Jantung Pada Pasien Hemodialisis

Yanis

Abdullah

Salwani

et al. 2022

JKS

View full text Add to dashboard Cite

Pendahuluan. Penyait Ginjal Stadium Akhir (end stage renal disease, ESRD) merupakan stadium Penyakit Ginjal Kronis (PGK) yang memerlukan terapi pengganti ginjal termasuk hemodialisis (HD). Indikator keberhasilan HD termasuk kinerja jantung dan kualitas hidup pasien diyakini tergantung pada indikator proses yang meliputi kecukupan (adekuasi) HD, kejadian anemia serta malfungsi akses vaskular dan infeksi. Tujuan. Penelitian ini bertujuan untuk menilai hubungan antara indikator proses dan indikator hasil pasien HD. Metode. Penelitian ini merupakan penelitian observasional analitik dengan pendekatan kohort yang melibatkan 350 pasien dari 5 unit HD di Provinsi Aceh. Data diperoleh dari rekam medis pasien, sedangkan kualitas hidup pasien HD dinilai dengan kuesioner Kidney Disease Quality of Life (KDQoL). Kinerja jantung dinilai dengan menggunakan ekokardiografi. Hasil. Hasil penelitian menunjukkan adanya hubungan positif yang signifikan antara hemoglobin (Hb) dan adekuasi HD dengan fraksi ejeksi pasien yang menjalani HD. Selain itu, penelitian ini juga menemukan hubungan positif yang signifikan antara Hb dan adekuasi dengan kualitas hidup pasien HD, terutama fungsi fisik dan kesejahteraan emosional. Kesimpulan. Adanya korelasi positif antara Hb dan adekuasi HD dengan kinerja jantung dan kualitas hidup menunjukkan pentingnya indikator proses dalam meningkatkan kualitas pelayanan HD serta pasien HD.

show abstract

Cardiovascular risk factors in children on dialysis: an update

Querfeld

Schaefer

2018

Pediatr Nephrol

View full text Add to dashboard Cite

Time-averaged hemoglobin values, not hemoglobin cycling, have an impact on outcomes in pediatric dialysis patients

Abstract: Hb cycling is common among dialysis patients. Severity of anemia rather than its cycling has more significant impact on the prevalence of LVH and on inflammatory state.

Cited by 4 publications

References 40 publications

Erythropoietin Resistance Index and the Affecting Factors in Children with Peritoneal Dialysis

Erythropoietin Resistance Index and the Affecting Factors in Children with Peritoneal Dialysis

Hemoglobin dan Adekuasi Berkorelasi dengan Kualitas Hidup dan Kinerja Jantung Pada Pasien Hemodialisis

Cardiovascular risk factors in children on dialysis: an update

Contact Info

Product

Resources

About