Time- and pH-Dependent Copper Binding to Aβ(1–16) Peptide: An Electrospray Ionization-Mass Spectrometric Approach

Abstract

An elevated concentration of copper ions in the brain of Alzheimer's disease (AD) patients has been reported in many studies and might be associated with an increased aggregation of -amyloid (A) peptides. In the present work, the interaction with copper ions of a model -