Time and frequency domain analyses of heart rate variability in patients with epilepsy

Evrengül, Harun; Tanrıverdi, Halil; Dursunoğlu, Dursun; Kaftan, Asuman; Kuru, Ömür; Unlu, Unal; Kılıç, Mustafa

doi:10.1016/j.eplepsyres.2005.02.001

Cited by 106 publications

(99 citation statements)

References 46 publications

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“…West syndrome is regarded as a form of generalized epilepsy characterized by hypsarrythmia. Evrengul et al (2005) demonstrated that patients with generalized tonic-clonic seizures have changes in HRV including increased LF power, although they also observed decreased power and increased LF/HF. We believe that etiological factors might not affect autonomic function, because the cryptogenic and symptomatic groups in the present study did not significantly differ.…”

Section: Discussionmentioning

confidence: 99%

Cardiac Vagal Activation by Adrenocorticotropic Hormone Treatment in Infants with West Syndrome

Hattori

Hayano

Fujimoto

et al. 2007

Tohoku J. Exp. Med.

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West syndrome (WS) is a generalized epileptic syndrome of infancy and early childhood with various etiologies, and consists of a triad of infantile spasm, arrest or regress of psychomotor development and specific electroencephalogram (EEG) pattern of hypsarrhythmia. WS had been believed to be refractory, but recent evidence supports effectiveness of adrenocorticotropic hormone (ACTH) treatment. The ACTH treatment, however, has a problem that it is often accompanied by adverse autonomic symptoms. We therefore examined heart rate variability (HRV) for assessing cardiac autonomic functions in WS and prospectively observed the changes during ACTH treatment. We studied 15 patients with WS and 9 age-matched controls during sleep (EEG stage 2). Compared with controls, the patients with WS were greater in the low-frequency component (LF) of HRV, an index reflecting sympatho-vagal interaction ( p = 0.02), but were comparable for high-frequency component (HF) and LF-to-HF ratio (LF/HF), indices reflecting cardiac vagal activity and sympathetic predominance, respectively. During ACTH treatment, heart rate decreased ( p < 0.01), LF and HF increased ( p < 0.01), and LF/HF did not differ significantly. These results indicate that West syndrome might be accompanied by autonomic changes and that ACTH treatment enhances parasympathetic function and causes bradycardia. West syndrome; ACTH; heart rate variability; bradycardia; autonomic function

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Section: Discussionmentioning

confidence: 99%

Cardiac Vagal Activation by Adrenocorticotropic Hormone Treatment in Infants with West Syndrome

Hattori

Hayano

Fujimoto

et al. 2007

Tohoku J. Exp. Med.

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“…This dysfunction results in higher morbidity and mortality in patients with epilepsy than in those without epilepsy (17). Frequency-domain analysis of heart rate variability (HRV) is a sophisticated and noninvasive tool for detecting autonomic regulation of the heart (11,14,(18)(19)(20)(21)(22)(23)(24).…”

Section: Introductionmentioning

confidence: 99%

Pre-ictal heart rate variability assessment of epileptic seizures by means of linear and non-linear analyses

Behbahani¹,

Dabanloo²,

Nasrabadi³

et al. 2013

Anadolu Kardiyol Derg

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Pre-ictal heart rate variability assessment of epileptic seizures by means of linear and non-linear analyses ABSTRACTObjective: The purpose of the present study was to analyze the effects of epilepsy on the autonomic control of the heart in pre-ictal phase in order to find an algorithm of early detection of seizure onset. Methods: Overall 133 epileptic seizures were analyzed from 12 patients with epilepsy (seven males and five females; mean age 43.91 years, SD: 10.16) participated in this study. Single lead electrocardiogram recordings of epileptic patients were compiled. 240, 90-30, 30-10 and 5 minutes heart rate variability (HRV) signals of preseizure were chosen for analysis of heart rate. As HRV signals are non-stationary, a set of time and frequency domain features (Mean HR, Triangular Index, LF, HF, LF/HF) and nonlinear parameters (SD1, SD2 and SD2/SD1 indices derived from Poincaré plots) extracted from HRV is analyzed. Statistical analysis was performed using paired sample t-test for comparisons of the segments and differences between pre-ictal segments were evaluated by Tukey tests. Results: There was slight tachycardia in segments near the seizure (30 minutes before: 85.3517 bpm, 5 minutes before: 119.3630.82 bpm, p=0.0207) which significantly differ from baseline in segments far from seizure (240 minutes before: 66.5211.7 bpm). Also there was significant increase in LF/ HF ratio (30 minutes before: 1.10.22, 5 minutes before: 2.120.5, p=0.0332) and SD2/SD1 ratio (30 minutes before: 1.20.15, 5 minutes before: 2.030.55, p=0.0431) when compared to segments far from the seizure (240 minutes before: 0.780.24 and 0.780.14) respectively. Although there was about decrease of triangular index in segments near the seizure the percentage of decrease was not comparable to segments far from the seizure. Conclusion: Significant changes of HRV parameters in pre-ictal (5 minutes before the seizure) are obviously higher in comparison to interictal baseline. Pre-ictal significant changes of HRV suggesting that this time can be considered as prediction time for designing an algorithm of early detection of seizure onset based on HRV. (

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“…An imbalance towards increased parasympathetic activity was also demonstrated by 123I metaiodobenzylguanidine-SPECT analysis (28). However the autonomic imbalance in the opposite direction, such as increased sympathetic and decreased parasympathetic activity, was demonstrated in a study of 49 patients with generalized tonicclonic seizures (29).…”

Section: Discussionmentioning

confidence: 99%

Abnormal Vasomotor System Function in Idiopathic Generalized Epileptic Patients

Maghbooli¹,

Langroudi²,

Ghoreishi³

et al. 2014

tnd

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Objective: Autonomic dysfunction is widely recognized in both partial and generalized epilepsies. The aim of this study was to evaluate the vasomotor response in patients with generalized idiopathic epilepsy using clinical autonomic function tests. Ma te ri als and Met hods: Hundred and twenty-four consecutive subjects including 62 idiopathic generalized epileptic patients diagnosed for more than 3 months receiving monotherapy and 62 matched for sex and age healthy controls were assessed in this case-control study. The evaluation of the vasomotor system was made using a questionnaire and autonomic function tests including cold pressor, Valsalva maneuver, mental arithmetic and hand-grip tests. Re sults: Abnormal score of the Cold pressor test was seen in 59.7%, Valsalva maneuver in 64.5% and 33.9% in mental arithmetic test of epileptic patients. These results were different significantly in comparison to control group. If abnormal hand grip test was defined as an increase less than 11 mmHg in diastolic pressure, there was found no significant difference between two groups of case and control, also a few people in control group was reported normal. When abnormality was defined as an increase in only one or none of the parameters of systolic blood pressure, diastolic blood pressure or heart rate, 43.5% in patient group versus 14.5% in controls had abnormal results with statistically significant difference. Conclusion: Vasomotor dysfunction assessed with cardiovascular tests was present in patients with generalized epilepsy. Further research on central and peripheral limbs in association with the breakdown of the system is required. (Turkish Journal of Neurology 2014; 20:126-131)

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Time and frequency domain analyses of heart rate variability in patients with epilepsy

Cited by 106 publications

References 46 publications

Cardiac Vagal Activation by Adrenocorticotropic Hormone Treatment in Infants with West Syndrome

Cardiac Vagal Activation by Adrenocorticotropic Hormone Treatment in Infants with West Syndrome

Pre-ictal heart rate variability assessment of epileptic seizures by means of linear and non-linear analyses

Abnormal Vasomotor System Function in Idiopathic Generalized Epileptic Patients

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