Time- and dose-dependent volume decreases in subcortical grey matter structures of glioma patients after radio(chemo)therapy

Raschke, Felix; Witzmann, Katharina; Seidlitz, Annekatrin; Wesemann, Tim; Jentsch, Christina; Platzek, Ivan; Hoff, Jörg van den; Kotzerke, Jörg; Beuthien‐Baumann, Bettina; Baumann, Michaël; Linn, Jennifer; Krause, Mechthild; Troost, Esther G.C.

doi:10.1016/j.ctro.2022.07.003

Cited by 4 publications

(2 citation statements)

References 37 publications

(64 reference statements)

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“…The study of the effects of radiotherapy on WM microstructure alterations and their translation into cognitive and motor deficits represent an expanding field of neuro-oncology research [123,124]. Beyond the preservation of essential cortical structures such as the hippocampus [125,126], it is now essential that future guidelines integrate current knowledge on LGG-induced plasticity and functional data obtained from awake surgery to adapt treatment planification. Modulations of therapeutic targets and multistage irradiations accounting for histomolecular data (e.g., MGMT status, 1p19q codeletion) and intrasurgical findings (critical functional WM tracts) may help to optimize the onco-functional balance and to delay cognitive declines [127].…”

Section: Radiotherapymentioning

confidence: 99%

Brain Plasticity Profiling as a Key Support to Therapeutic Decision-Making in Low-Grade Glioma Oncological Strategies

Duffau

2023

Cancers

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The ability of neural circuits to compensate for damage to the central nervous system is called postlesional plasticity. In diffuse low-grade gliomas (LGGs), a crosstalk between the brain and the tumor activates modulations of plasticity, as well as tumor proliferation and migration, by means of paracrine and electrical intercommunications. Such adaptative mechanisms have a major impact on the benefits and risks of oncological treatments but are still disregarded by current neuro-oncological guidelines. In this review, the authors first aimed to highlight clinical, radiological, and oncological markers that robustly reflect the plasticity potentials and limitations in LGG patients, including the location of the tumor and the degree of critical white matter tract infiltration, the velocity of tumor expansion, and the reactional changes of neuropsychological performances over time. Second, the interactions between the potential/limitations of cerebral plasticity and the efficacy/tolerance of treatment options (i.e., surgery, chemotherapy, and radiotherapy) are reviewed. Finally, a longitudinal and multimodal treatment approach accounting for the evolutive profiles of brain plasticity is proposed. Such an approach integrates personalized predictive models of plasticity potentials with a step-by-step therapeutic decision making and supports onco-functional balanced strategies in patients with LGG, with the ultimate aim of optimizing overall survival and quality of life.

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Section: Radiotherapymentioning

confidence: 99%

Brain Plasticity Profiling as a Key Support to Therapeutic Decision-Making in Low-Grade Glioma Oncological Strategies

Duffau

2023

Cancers

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“…However, the current comprehensive treatment has certain side effects, such as incomplete removal by surgery, destruction of functional areas, and indiscriminate killing of normal nerve cells and glioma cells by radioactive elements during radiation therapy [20,21]. Chemotherapy, in contrast, is not only limited by the drug tolerance of glioma (e.g., platinum-based chemotherapeutic agents, a class of chemotherapeutic agents that affect the cell cycle, are not effective, because gliomas are resistant to platinum-based drugs [22]) but also decreases neurocognitive and other functions [23,24].…”

Section: Introductionmentioning

confidence: 99%

Precise Control of Glioma Cell Apoptosis Induced by Micro-Plasma-Activated Water (μ-PAW)

Zhang¹,

Du²,

Shi³

et al. 2022

Micromachines

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To verify the existence of plasma with the potential to kill tumor cells, this paper designed a novel helium (He) micro-plasma jet array device and detected the concentration of typical long-lived reactive oxygen and nitrogen species (RONS) with oxidative activity generated by it. The paper described a new He micro-plasma jet array device consisting of nine flexible quartz capillaries with an inner diameter of 75 μm arranged in a 3 × 3 array. Sterilized ultrapure water (up water) was first treated with the He micro-plasma jet array device to activate it to form enriched RONS micro-plasma-activated water (μ-PAW), and then μ-PAW was added to the cell culture medium (with cells) to observe the proliferation of human glioma cells. The concentration of long-lived RONS, such as nitrate (NO3−), was detected according to Beer–Lambert’s law in combination with UV spectrophotometry as well as a color development method. The MTT Cell Proliferation and Cytotoxicity Assay Kit combined with the Hoechst Staining Kit were used to assess the proliferation status of the cells. The results showed that the range of RONS concentration variation could be controlled in the order of micromoles (µmol), while plasma-induced tumor cell death is apoptosis that does not affect the surrounding environment.

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Artificial intelligence and radiation effects on brain tissue in glioblastoma patient: preliminary data using a quantitative tool

Franco¹,

Granata²,

Fusco³

et al. 2023

Radiol med

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Time- and dose-dependent volume decreases in subcortical grey matter structures of glioma patients after radio(chemo)therapy

Cited by 4 publications

References 37 publications

Brain Plasticity Profiling as a Key Support to Therapeutic Decision-Making in Low-Grade Glioma Oncological Strategies

Brain Plasticity Profiling as a Key Support to Therapeutic Decision-Making in Low-Grade Glioma Oncological Strategies

Precise Control of Glioma Cell Apoptosis Induced by Micro-Plasma-Activated Water (μ-PAW)

Artificial intelligence and radiation effects on brain tissue in glioblastoma patient: preliminary data using a quantitative tool

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