“…Key mechanisms leading to enhanced new bone growth are now known to be related to the controlled release of ionic dissolution products from the degrading bioactive glass, especially critical concentrations of biologically active, soluble silica and calcium ions [8,191]. Recent studies have shown that bioactive (partially) resorbable glasses and their ionic dissolution products enhance osteo-genesis by regulating osteoblast proliferation, differentiation, and gene expression [7,41,51,191,192,193,194,195,196,197,198]. …”