1959
DOI: 10.1161/01.cir.19.3.430
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Time and Concentration Components of Indicator-Dilution Curves Recorded Following Central Injections of Dye in Normal Human Subjects

Abstract: Indicator-dilution curves were recorded by oximiieters at tlme ears anld the right radial artery following the injection of Evans blue (T 1824) into the superior vena cava and pulmonary arteries of 37 subjects who had no evidence of cardiovascular disease. The variability and ranges of various time and concentration components of these dilution curves are presented. These values can be used as standards of reference in the interpretation of abnormal dilution curves. Some of the factors responsible for the vari… Show more

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Cited by 16 publications
(8 citation statements)
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“…Both groups used slug injections of dye and a single sampling site; a method, which was shown by Lange et al (1966) to prolong the MTT-T D difference by some 6 s due to dispersion of the dye signal at the site of injection without affecting the MTT value. This would explain why there is a good agreement between the MTT values of Carter et al (1959) and the resting MTT values of the present investigation (19.5 and 18.2 s, respectively), while values for the MTT T D difference deviate.…”
Section: Blood Flow and Circulatory Transfer During Rest And Exercisesupporting
confidence: 69%
See 1 more Smart Citation
“…Both groups used slug injections of dye and a single sampling site; a method, which was shown by Lange et al (1966) to prolong the MTT-T D difference by some 6 s due to dispersion of the dye signal at the site of injection without affecting the MTT value. This would explain why there is a good agreement between the MTT values of Carter et al (1959) and the resting MTT values of the present investigation (19.5 and 18.2 s, respectively), while values for the MTT T D difference deviate.…”
Section: Blood Flow and Circulatory Transfer During Rest And Exercisesupporting
confidence: 69%
“…However, Carter et al (1959) have measured the pulmonary-artery to radial-artery MTT in healthy supine adults at rest and found it to be 19.5 s, while T D was 11.7 s. Grace et al (1957) report a right heart-to-radial artery T D of 10.7 s in resting subjects. Both groups used slug injections of dye and a single sampling site; a method, which was shown by Lange et al (1966) to prolong the MTT-T D difference by some 6 s due to dispersion of the dye signal at the site of injection without affecting the MTT value.…”
Section: Blood Flow and Circulatory Transfer During Rest And Exercisementioning
confidence: 99%
“…Normally from the right atrium to the ear the time is approximately 10 sec. (Carter et al, 1959). It varies with the length of passage of the dye, the volume of fluid through which it flows, and the cardiac output.…”
Section: Methodsmentioning
confidence: 99%
“…Most of these have been discussed in the prior sections of this symposium and will not be touched on further here; they are, however, undoubtedly responsible for the relatively wide range of values for the various components of arterial dilution curves recorded from normal subjects. 38 In addition to these more or less nonspecific factors in the circulation that affect the contour of dilution curves, it would be expected that any abnormal communication in the circulatory system that significantly decreases or increases the transit time of a portion of the blood traversing the central circulation would produce specific effects on the contour of the dilution curve. Such abnormal communications, that is, intracardiac or great-vessel defects, are usually the result of congenital heart disease and are usually associated with abnormal circulatory shunts either in the right-to-left or the left-to-right direction.…”
Section: Figurementioning
confidence: 99%