Time after time: circadian clock regulation of intestinal stem cells

Parasram, Kathyani; Karpowicz, Phillip

doi:10.1007/s00018-019-03323-x

Cited by 22 publications

(18 citation statements)

References 303 publications

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“…Intestinal cell growth, proliferation, differentiation and gut microbiome had a daily rhythm orchestrated by circadian clock genes [57,58]. Per1 and Per2 were expressed rhythmically throughout the gastrointestinal tract and had been shown to coordinate gastrointestinal functions such as motility, cell proliferation and migration, and regulate host gut microbiota rhythms [59,60].…”

Section: Plos Onementioning

confidence: 99%

Low circadian clock genes expression in cancers: A meta-analysis of its association with clinicopathological features and prognosis

Zhang

et al. 2020

PLoS ONE

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Background Per1, Per2, Per3, Cry1, Cry2, Bmal1, Npas2 and CLOCK genes are the eight core circadian clock genes. Low expression of these circadian clock genes plays an important role in the progression of cancers. However, its clinicopathological and prognostic value in patients with cancers remains controversial and inconclusive. We performed a meta-analysis of studies assessing the clinicopathological and prognostic significance of low expression of these genes in cancers. Methods Relevant studies were searched from the Cochrane Central Register of Controlled Trials, Embase, EBSCO, Ovid, PubMed, Science Direct, Wiley Online Library database, CNKI and Wan Fang database. The meta-analysis was performed by using STATA version 12 software. A random-effect model was employed to evaluate all pooled hazard ratios (HRs) and odd ratios (ORs). Results A total of 36 studies comprising 7476 cases met the inclusion criteria. Meta-analysis suggested that low expression of Per1 was associated with poor differentiation (Per1: OR=2.

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Section: Plos Onementioning

confidence: 99%

Low circadian clock genes expression in cancers: A meta-analysis of its association with clinicopathological features and prognosis

Zhang

et al. 2020

PLoS ONE

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“…We found that expression of the circadian clock genes per1 and timeless that are typically synchronized, show the opposite expression pattern in the hindguts of cavefish and F1 hybrids. Proliferation and gene expression in the intestine is under circadian control and disruption of clock genes alters renewal of the epithelium (46)(47)(48). Having evolved in complete darkness, cavefish have altered circadian rhythm as evidenced by developmentally delayed and reduced amplitude of clock gene expression, lack of circadian cycles of metabolism, and reduced sleep (25,(49)(50)(51).…”

Section: Discussionmentioning

confidence: 99%

Evolution of gastrointestinal tract morphology and plasticity in cave-adapted Mexican tetra, Astyanax mexicanus

Riddle

Damen

Aspiras

et al. 2019

Preprint

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The gastrointestinal tract has evolved in numerous ways to allow animals to optimally assimilate energy from different food sources. The morphology and physiology of the gut is plastic and can be greatly altered by diet in some animals. In this study, we investigate the evolution and plasticity of gastrointestinal tract morphology by comparing laboratory raised cave-adapted and river-adapted forms of the Mexican tetra, Astyanax mexicanus reared under different dietary conditions. In the wild, river-dwelling populations (surface fish) consume plants and insects throughout the year, while cavedwelling populations (cavefish) live in a perpetually-dark environment dependent on nutrient-poor food brought in by bats or seasonal floods. We find that multiple cave populations converged on a reduced number of digestive appendages called pyloric caeca and that some cave populations have a lengthened gut while others have a shortened gut.Moreover, we identified differences in how gut morphology and proliferation of the epithelium respond to diet between surface fish and cavefish. Using a combination of quantitative genetic mapping, population genetics, and RNA sequencing we implicate molecular and genetic changes influencing cell proliferation, cell signaling, and immune system function in the evolution of gut morphology.

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“…Nonetheless, during the regenerative response to irradiation, intestinal epithelial proliferation occurs in Bmal1dependent circadian cycles (Stokes et al, 2017). Discrepancies in results may be due to different regulation of proliferative cycles of cells in vitro or under homeostatic versus regenerative conditions in vivo (see an extensive review in Parasram and Karpowicz, 2020). Interestingly, IESCs in flies have transcriptional oscillations of the core clock components in vivo that seem to depend on communication with the niche (Karpowicz et al, 2013;Parasram et al, 2018).…”

Section: Intestinal Epithelial Scsmentioning

confidence: 99%