Tilted pillar array fabrication by the combination of proton beam writing and soft lithography for microfluidic cell capture Part 2: Image sequence analysis based evaluation and biological application

Járvás, Gábor; Varga, Tamás; Szigeti, Márton; Hajba, László; Fürjes, Péter; Rajta, I.; Guttman, András

doi:10.1002/elps.201700268

Cited by 1 publication

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“…In particular, it has received attention for the in situ characterization of cells after trapping them using microfluidic device equipped with microwell arrays [18,19]. There are traditional methods for fabricating microfluidic devices such as soft lithography, photolithography, and laser direct writing [20,21,22]. Although photolithography has the advantages of high resolution, a physical mask is essential during the fabrication process, and this technique requires extreme environmental conditions.…”

Section: Introductionmentioning

confidence: 99%

Facile Method for Fabricating Microfluidic Chip Integrated with Microwell Arrays for Cell Trapping

Wang

et al. 2019

Micromachines

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With the development of biomedical technology, personalized diagnosis and treatment at the single-cell level are becoming more important in the medical field. As one of the most powerful tools, microfluidic chips have shown significant potential for various applications related to cell separation, cell proliferation, and cell behavior analysis. However, fabricating microfluidic devices requires complicated procedures and high-cost equipment. In this study, an optofluidic maskless lithography method was proposed for rapid fabrication of microfluidic devices integrated with microwells. Through the use of this approach, microwells can be on-line designed and the exposure patterns can be modulated. Single or multi polystyrene microspheres were successfully trapped by using the designed microwells. The capture of MCF-7 cells and cell arrays indicated that the microfluidic devices fabricated in the present study can be applied for cell research.

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Section: Introductionmentioning

confidence: 99%

Facile Method for Fabricating Microfluidic Chip Integrated with Microwell Arrays for Cell Trapping

Wang

et al. 2019

Micromachines

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Tilted pillar array fabrication by the combination of proton beam writing and soft lithography for microfluidic cell capture Part 2: Image sequence analysis based evaluation and biological application

Abstract: Abstractwww.electrophoresis-journal.com Page 2 ElectrophoresisThis article is protected by copyright. All rights reserved.

Cited by 1 publication

References 14 publications

Facile Method for Fabricating Microfluidic Chip Integrated with Microwell Arrays for Cell Trapping

Facile Method for Fabricating Microfluidic Chip Integrated with Microwell Arrays for Cell Trapping

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