Tilted Fiber Bragg Grating Active Heater for Controlled and Localised Hyperthermia

Abstract

We present data from localized heat inducement studies at both cellular and tissue levels along with a computational model built to predict the temperature increase and damage extent in tissues receiving hyperthermia treatment by a fiber-based active heater. This novel fiber-based active heater serves as a heat source and a temperature sensor. Five important insights are highlighted from this thesis work.First, heat-induced controlled cell deaths were observed experimentally in the three cell lines with MCF-10A being more susceptible to heat compared to HEK 293 and MCF7 cells. Second, comparison between the phantom tissue and ex vivo experimental and computational results shows a lesion size of 5×12 mm and 4.87×11.6 mm in the phantom tissue and 7×15 mm and 8.8×14.3 mm in the ex vivo studies at pumping power of 1.8 W for 10 minutes respectively. Thus, this computational model is able to provide information about the heat transfer characteristics caused by the active heater in living biological tissue.