Tilapia adropin: the localization and regulation of growth hormone gene expression in pituitary cells

Peng, Jianpeng; Yang, Ping; Zhang, Qianli; Jiang, Qiqi

doi:10.1016/j.peptides.2017.09.009

Cited by 7 publications

(4 citation statements)

References 55 publications

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“…VIP plot highlighted that 10-HDA followed by decanedioic acid then 8-hydroxyoctanoic acid as the most influencing chemical markers on the OPLS model by possessing a threshold value greater than one. These results came in agreement with the study performed by Peng, et al 11 where 10-HDA exhibited significant reduction in B16F1 melanoma cells viability at a concentration of 1 mM. However, the study attributed the anti-melanoma activity of RJ to a single fatty acid (10-HDA) rather than considering the entire fatty acids profile.…”

Section: Resultssupporting

confidence: 92%

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Royal jelly fatty acids bioprofiling using TLC-MS and digital image analysis coupled with chemometrics and non-parametric regression for discovering efficient biomarkers against melanoma

Ibrahim

El‐Banna

2021

RSC Adv.

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Section: Resultssupporting

confidence: 92%

“…These supplements are claimed to be anti-oxidant, 3 immunostimulant, 4 anti-aging, 5 anti-hypercholesterolemic, 6 anti-inflammatory, 7 anti-tumor, 8 wound-healing, 9 antibacterial 10 and skin whitening agents. 11 …”

Section: Introductionmentioning

confidence: 99%

Royal jelly fatty acids bioprofiling using TLC-MS and digital image analysis coupled with chemometrics and non-parametric regression for discovering efficient biomarkers against melanoma

Ibrahim

El‐Banna

2021

RSC Adv.

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“…In mammals, these GPCRs are activated by peptides that relate to diverse physiological functions [ 89 , 90 , 91 , 92 ]. In fish, adropin and neuropeptide W/neuropeptide B (NPWB) were associated with GH regulation [ 93 ]; however, their regulation in the HPG axis is unknown. However, relaxin-3was previously found to increase LH secretion in the rat [ 94 ], and increased lhβ and fshβ transcription in immortalized mouse gonadotrophs (LβT2 cells) [ 95 ].…”

Section: Resultsmentioning

confidence: 99%

Differential Regulation of Gonadotropins as Revealed by Transcriptomes of Distinct LH and FSH Cells of Fish Pituitary

Hollander-Cohen

Golan

Levavi‐Sivan

2021

IJMS

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From mammals to fish, reproduction is driven by luteinizing hormone (LH) and follicle-stimulating hormone (FSH) temporally secreted from the pituitary gland. Teleost fish are an excellent model for addressing the unique regulation and function of each gonadotropin cell since, unlike mammals, they synthesize and secrete LH and FSH from distinct cells. Only very distant vertebrate classes (such as fish and birds) demonstrate the mono-hormonal strategy, suggesting a potential convergent evolution. Cell-specific transcriptome analysis of double-labeled transgenic tilapia expressing GFP and RFP in LH or FSH cells, respectively, yielded genes specifically enriched in each cell type, revealing differences in hormone regulation, receptor expression, cell signaling, and electrical properties. Each cell type expresses a unique GPCR signature that reveals the direct regulation of metabolic and homeostatic hormones. Comparing these novel transcriptomes to that of rat gonadotrophs revealed conserved genes that might specifically contribute to each gonadotropin activity in mammals, suggesting conserved mechanisms controlling the differential regulation of gonadotropins in vertebrates.

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“…Irisin directly inhibits the gene expression and secretion of growth hormone when using primary tilapia pituitary cells. And atropin could stimulate the expression of genes related to growth hormone via direct action at the pituitary level [27,28].…”

Section: Fish Pituitary Cellsmentioning

confidence: 99%

Profiling the Physiological Roles in Fish Primary Cell Culture

He,

Zhao,

Xiao

et al. 2023

Biology

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Fish primary cell culture has emerged as a valuable tool for investigating the physiological roles and responses of various cell types found in fish species. This review aims to provide an overview of the advancements and applications of fish primary cell culture techniques, focusing on the profiling of physiological roles exhibited by fish cells in vitro. Fish primary cell culture involves the isolation and cultivation of cells directly derived from fish tissues, maintaining their functional characteristics and enabling researchers to study their behavior and responses under controlled conditions. Over the years, significant progress has been made in optimizing the culture conditions, establishing standardized protocols, and improving the characterization techniques for fish primary cell cultures. The review highlights the diverse cell types that have been successfully cultured from different fish species, including gonad cells, pituitary cells, muscle cells, hepatocytes, kidney and immune cells, adipocyte cells and myeloid cells, brain cells, primary fin cells, gill cells, and other cells. Each cell type exhibits distinct physiological functions, contributing to vital processes such as metabolism, tissue regeneration, immune response, and toxin metabolism. Furthermore, this paper explores the pivotal role of fish primary cell culture in elucidating the mechanisms underlying various physiological processes. Researchers have utilized fish primary cell cultures to study the effects of environmental factors, toxins, pathogens, and pharmaceutical compounds on cellular functions, providing valuable insights into fish health, disease pathogenesis, and drug development. The paper also discusses the application of fish primary cell cultures in aquaculture research, particularly in investigating fish growth, nutrition, reproduction, and stress responses. By mimicking the in vivo conditions in vitro, primary cell culture has proven instrumental in identifying key factors influencing fish health and performance, thereby contributing to the development of sustainable aquaculture practices.

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Tilapia adropin: the localization and regulation of growth hormone gene expression in pituitary cells

Cited by 7 publications

References 55 publications

Royal jelly fatty acids bioprofiling using TLC-MS and digital image analysis coupled with chemometrics and non-parametric regression for discovering efficient biomarkers against melanoma

Royal jelly fatty acids bioprofiling using TLC-MS and digital image analysis coupled with chemometrics and non-parametric regression for discovering efficient biomarkers against melanoma

Differential Regulation of Gonadotropins as Revealed by Transcriptomes of Distinct LH and FSH Cells of Fish Pituitary

Profiling the Physiological Roles in Fish Primary Cell Culture

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