Tigliane-Type Diterpene Esters from<i>Synadenium grantii</i><sup>1,5</sup>

Bagavathi, R.; Sorg, B.; Hecker, Erich

doi:10.1055/s-2006-962531

Cited by 20 publications

(18 citation statements)

References 13 publications

(20 reference statements)

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“…14 Terpenes that are present in latex as well as other parts of the S grantii are described as presenting cytotoxic activity. 7,8 –10 Interestingly, the majority of the compounds previously described as active principles for this plant 8,9 –14 are different from those evidenced in our studies with subfractions 11 to 15 and 16 to 19, as evaluated by spectroscopic (NMR) and chromatographic methods (TLC and HPLC).…”

Section: Discussioncontrasting

confidence: 85%

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Antiproliferative Effect of Synadenium grantii Hook f. stems (Euphorbiaceae) and a Rare Phorbol Diterpene Ester

et al. 2016

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Synadenium grantii is frequently used for the treatment of various diseases such as allergies, gastric disorders, and especially cancer. The aim of this study was to evaluate the possible antiproliferative potential of the methanol extract, fractions, and pure compounds from the stems of S grantii Phytochemical analysis was carried out by conventional chromatographic techniques, and the antiproliferative activity was analyzed using the sulforhodamine B assay and an MTT-based assay. Nonpolar fraction and its subfractions from the stems of S grantii exhibited promising cytostatic effect against several human tumor cell lines (glioma, breast, kidney, and lung), with total grown inhibition values ranging from 0.37 to 2.9 μg/mL. One of the active principles of this plant was identified as a rare phorbol diterpene ester, denoted as 3,4,12,13-tetraacetylphorbol-20-phenylacetate. This compound demonstrated antiproliferative activity against glioma, kidney, lung, and triple-negative breast cancer cell lines. These results demonstrate that S grantii stems produce active principles with relevant antiproliferative potential.

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Section: Discussioncontrasting

confidence: 85%

“…7 Some other compounds have been found in this plant, such as diterpene esters, anthocyanins, and unsaponificable substances. 6 –10…”

Section: Introductionmentioning

confidence: 99%

Antiproliferative Effect of Synadenium grantii Hook f. stems (Euphorbiaceae) and a Rare Phorbol Diterpene Ester

et al. 2016

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“…Diterpene tigliane esters are characteristic of the Synadenium genus, and can be indicated as chemotaxonomic markers and can also be responsible for skin irritant proprieties (Evans, 1986;Bagavathi et al, 1988).…”

Section: Resultsmentioning

confidence: 99%

Anti-ulcer activity of Synadenium grantii latex

Costa¹,

David²,

Pinto³

et al. 2012

Rev. bras. farmacogn.

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Synadenium grantii Hook f., Euphorbiaceae, is popularly known as leitosinha or janaúba. The diluted latex (18 drops/L of water) is commonly used in the south of Brazil to treat gastric disturbances. This study evaluated phytochemical screening and toxicity using Artemia salina Leach of crude bark extract and also latex. The toxicity and the anti-ulcer activity of S. grantii latex were also tested in rats. Phytochemical results showed presence of tannins, terpenes, unsaponificable substances, coumarins and anthraquinones in the crude bark extract and terpenes in the latex. Gas chromatography-mass spectrometry (GC-MS) analysis demonstrated the presence of diterpene tigliane esters in the latex, identified as 12-deoxyphorbol-13-(2-metilpropionate) and phorbol 12,13,20-triacetate. The toxicity results using A. salina presented CL50 26.58μg/mL and CL50 778.66μg/mL, for the latex and the crude bark extract respectively. The toxicological hepatic parameters of the diluted latex were not different to the control group (p<0.05). The eosinophils cells showed an increase in both the diluted and pure latex groups. The pure latex showed gastric protection of 90% (p<0.05) and the diluted latex showed 6% compared to the negative control. Therefore, our data indicate that S. grantii latex, under research conditions presented gastric protection. Pure latex showed more toxicity than the diluted latex.

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“…Block et al (2005), Jassbi (2006) and Aliabadi et al (2009) attribute this antitumoural activity to nonpolar constituents such as terpenoids that are very abundant in the chemical constitution of the Euphorbiaceae family. Terpenes that are present in latex as well as other parts of several species of the genus Synadenium are described to present cytotoxic activity (Bagavathi et al, 1988;Olivier et al, 1992;Bittner et al, 2001;Costa et al, 2012;Hassan et al, 2012). The 1 H and 13 C NMR spectra of hexane, chloroform and ethyl acetate fractions of the latex showed characteristic signals due to terpenes.…”

Section: Discussionmentioning

confidence: 99%