Abstract:e21110 Background: Immune checkpoint inhibitors (ICIs) have emerged as effective treatments for multiple cancers. TIGIT is an emerging ICI target that impairs T cell activation by dendritic cells, enhances the immune suppressive activity of regulatory T cells, and inhibits tumor killing by natural killer and cytotoxic T cells. In this study, we describe the mRNA expression landscape of TIGIT across 35 solid tumor types, its co-expression with additional checkpoint targets, and correlation with survival of pat… Show more
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