2021
DOI: 10.1080/08820139.2021.1904976
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TIGIT and CD155 as Immune-Modulator Receptor and Ligand on CD4+T cells in Preeclampsia Patients

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Cited by 17 publications
(9 citation statements)
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“…100 Recent studies have shown that the proportion of Tigit + CD4 + , Tigit + CD8 + T cells in the peripheral blood of PE patients is significantly decreased compared to controls. 99,101 Decreased CD226 expression and increased CD112 and CD155 surface expression were found in all T cell, NK cell, and monocyte subpopulations in women diagnosed with PE compared to the healthy group. 99 Blocking Tigit (PxxP, two in CD28 and one in CTLA-4).…”
Section: Tigit Signaling In Normal Pregnancy and Pregnancy Complicationsmentioning
confidence: 99%
“…100 Recent studies have shown that the proportion of Tigit + CD4 + , Tigit + CD8 + T cells in the peripheral blood of PE patients is significantly decreased compared to controls. 99,101 Decreased CD226 expression and increased CD112 and CD155 surface expression were found in all T cell, NK cell, and monocyte subpopulations in women diagnosed with PE compared to the healthy group. 99 Blocking Tigit (PxxP, two in CD28 and one in CTLA-4).…”
Section: Tigit Signaling In Normal Pregnancy and Pregnancy Complicationsmentioning
confidence: 99%
“…A study about unexplained recurrent miscarriage patients and normal pregnancy showed that an increased expression of TIGIT in the decidual γδT cells significantly plays essential roles in maintaining pregnancy, 126,127 which was also confirmed in a study of patients with pre-eclampsia. 128 Fu et al detected the expression of TIGIT in decidual immune cells at the maternal-fetal interface. Then by generating recombinant TIGIT-Fc fusion proteins, they confirmed that treatment with TIGIT-Fc of human decidual immune cells could increase IL-10 production, leading the decidual CD4 + T cells to a Th2 phenotype, suggesting that TIGIT-Fc fusion protein has therapeutic potential in pregnancy failure.…”
Section: Human Pregnancy and Pregnancyrelated Diseasesmentioning
confidence: 99%
“…Peripheral and decidual Treg cells increase during normal pregnancy. 10,11 Tregs exert suppressive functions through different mechanisms, including the modulation of antigen presentation, the cytolysis of target cells, and the secretion of inhibiting cytokines. 12,13 Treg cells prevent the operation and proliferation of Th17 and Th1 cells via different mechanisms, including programmed cell death protein 1 (PD-1) and the Ca + influx-clapin-caspase 1 pathway.…”
Section: Lymphoc Y Te S and Preg Nan C Ymentioning
confidence: 99%
“…Additionally, Treg cells are the main factors for immunological tolerance, the acceptance of the fetus by the mother's immune system, and embryo implantation. Peripheral and decidual Treg cells increase during normal pregnancy 10,11 . Tregs exert suppressive functions through different mechanisms, including the modulation of antigen presentation, the cytolysis of target cells, and the secretion of inhibiting cytokines 12,13 .…”
Section: Lymphocytes and Pregnancymentioning
confidence: 99%