Tight Skin 2 Mice Exhibit Delayed Wound Healing Caused by Increased Elastic Fibers in Fibrotic Skin

Long, Kristen B.; Burgwin, Chelsea M.; Huneke, Richard B.; Artlett, Carol M.; Blankenhorn, Elizabeth P.

doi:10.1089/wound.2014.0529

Cited by 9 publications

(8 citation statements)

References 30 publications

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“…In agreement, it was postulated that angiogenesis and matrix remodeling developing in wound healing are promoted by activation of cell cycle and cell proliferation executed in a timely and orderly manner [21] . In addition, collagen has a well-established function in wound healing [22] . It is the main component which strengthens and supports extra cellular tissue [23] .…”

Section: Discussionmentioning

confidence: 99%

Histological study on the effect of garlic extract on induced wound in male rat: Possible role of endogenous stem cells

Reda

Fattah

Helmi

et al. 2017

Journal of Medical Histology

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Background and Objectives: Chronic wounds represent a significant health problem. Novel therapeutic approaches to wound healing are required. Garlic (Allium sativum) was considered to exert antioxidant, antibacterial, and anticholesterol activities. Aim of the work: The present work aimed at investigating the possible therapeutic effect of garlic extract (GE) on induced wound in male albino rat. The possible role of endogenous stem cells was also determined. Materials and Methods: 26 adult male albino rats were divided into Group I (Control group): 6 rats not exposed to wound induction.Group II (Wounded group): 10 rats were exposed to wound induction and subdivided into subgroups IIa and IIb, 5 animals each, were sacrificed 2 and 3 weeks following wound induction. Group III (Wounded and GE treated group): 10 rats were exposed to wound induction and subdivided as in group II. 0.5 ml of 1% GE was locally applied following wound induction. Skin specimens (including the wound and a margin of normal skin around) were subjected to histological, immunohistochemical, morphometric and statistical studies. Results: Morphological changes, indicating inflammation and degeneration, were found in wounded rats. These changes regressed remarkably by the use of GE. The regression of apoptosis was confirmed by caspase3 immunostaining and the activation of stem cells was proved by CD44 immunostaining. Conclusions: GE therapeutic effect was proved to be related to both caspase3 pathway inactivation and MSC migration activation. GE was suggested to be applied in appropriate concentrations in the preparation of pharmaceutical products to be used safely on epithelial cells in wound care.

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Section: Discussionmentioning

confidence: 99%

Histological study on the effect of garlic extract on induced wound in male rat: Possible role of endogenous stem cells

Reda

Fattah

Helmi

et al. 2017

Journal of Medical Histology

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“…However, as a model for trauma-induced fibrosis, such as keloids, neither model adequately recapitulates the disease. Wound healing in both Tsk models is delayed, occurring 5–6 weeks post-injury compared with 2–3 weeks in wild-type (WT) mice [4,6]. This is thought to be due, in part, to the structural and tensile forces the surrounding skin has on the forming granulation tissue.…”

Section: Animal Modelsmentioning

confidence: 99%

“…This is thought to be due, in part, to the structural and tensile forces the surrounding skin has on the forming granulation tissue. Once sufficient granulation tissue has formed, the tensile force it exerts over the surrounding wound edge exceeds that of the surrounding wound edge and wound closure slowly occurs [4,6]. Both Tsk strains offer a unique vantage point into systemic cutaneous fibrosis in the mouse, and have proven useful for studying other forms of fibrosis.…”

Section: Animal Modelsmentioning

confidence: 99%

Keloids: Animal models and pathologic equivalents to study tissue fibrosis

et al. 2016

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“…Otherwise, dermal fibroblasts from Tsk/+ mice exhibit an increased basal activity of the TGF-beta1 promoter [22] and Tsk/+ and Tsk2 mice display some abnormalities in wound healing. Indeed, the wound contraction is delayed because of a decrease in collagenase activity and a dysregulation in elastic fiber [23,24]. Regarding lung features, histological examinations revealed emphysema-like changes, characterized by enlargement of air spaces accompanied by the destruction of alveolar walls [25].…”

Section: F Batteuxmentioning

confidence: 99%

Animal Models of Systemic Sclerosis

Morin¹,

Kavian²,

Batteux³

2015

CPD

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Systemic sclerosis is a systemic connective tissue disorder characterized by the fibrosis of the skin and certain visceral organs, vasculopathy, and immunological abnormalities. Several genetic and inducible animal models of SSc have been developed and are available for research studies. The purpose of this review is to summarize the various animal models of systemic sclerosis and describe the various contributions of these models in terms of understanding the pathophysiology of the condition and searching for new therapeutic strategies for this incurable disease.

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Tight Skin 2 Mice Exhibit Delayed Wound Healing Caused by Increased Elastic Fibers in Fibrotic Skin

Cited by 9 publications

References 30 publications

Histological study on the effect of garlic extract on induced wound in male rat: Possible role of endogenous stem cells

Histological study on the effect of garlic extract on induced wound in male rat: Possible role of endogenous stem cells

Keloids: Animal models and pathologic equivalents to study tissue fibrosis

Animal Models of Systemic Sclerosis

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