2014
DOI: 10.1016/j.gene.2014.09.011
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Tight, cell type-specific control of LNX expression in the nervous system, at the level of transcription, translation and protein stability

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Cited by 13 publications
(44 citation statements)
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“…LNX2 protein is detectable at embryonic and early postnatal stages, but decreases dramatically thereafter. Given that Lnx2 mRNA expression persists into adulthood, the downregulation of LNX2 expression seems to be occurring post transcriptionally, possibly at the level of translation as has been described for LNX1 [ 2,11 ], although a high protein turnover rate may also contribute to the low levels of LNX proteins observed in vivo.…”
Section: Discussionmentioning
confidence: 89%
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“…LNX2 protein is detectable at embryonic and early postnatal stages, but decreases dramatically thereafter. Given that Lnx2 mRNA expression persists into adulthood, the downregulation of LNX2 expression seems to be occurring post transcriptionally, possibly at the level of translation as has been described for LNX1 [ 2,11 ], although a high protein turnover rate may also contribute to the low levels of LNX proteins observed in vivo.…”
Section: Discussionmentioning
confidence: 89%
“…We have previously shown that this line, which we refer to as Lnx1 , lacks expression of the neuronally expressed LNX1 p70 and p62 protein isoforms (Fig. 1 c) [ 11 ]. Comprehensive phenotyping of this line, which included some basic neurological and behavioural tests, did not reveal any significant findings apart from an increased percentage of B1like B cells in peritoneal lavage ( https://www.mmrrc.org/catalog/sds.php?mmrrc_id=32436 ).…”
Section: Generation Of Lnx 1/2 Double Knockout Micementioning
confidence: 89%
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