Tigecycline-induced Drug Fever and Leukemoid Reaction

Shao, Qianqian; Qin, Ling; Ruan, Gui-Ren; Chen, Ruxuan; Luan, Zi-Jian; Ma, Xiaojun

doi:10.1097/md.0000000000001869

Cited by 10 publications

(5 citation statements)

References 6 publications

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“…To the best of our knowledge, there are few reports of DF induced by imipenem/cilastatin. The body is more sensitive to the drug in elderly patients who have taken different kinds of antibiotics [Shao 2015]. Hypersensitivity is considered to be a type III allergic reaction [Ochi 2011].…”

Section: E122mentioning

confidence: 99%

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Unusual Drug Fever Caused by Imipenem/Cilastatin and a Review of Literature

Yang

Wang

et al. 2019

HSF

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Introduction: Drug fever is a febrile reaction caused by initiation of one drug or varieties of drugs and often disappears after cessation of the drug(s). Clinically, drug fever is frequently induced by antibiotics, anticonvulsants, and antineoplastics. There are few previous reports about drug fever caused by imipenem/cilastatin. Case Presentation: Here, we described a 66-year-old man undergoing the Ivor Lewis esophagectomy for esophageal carcinoma, who developed drug fever. The patient had a high temperature with shivering after administration of imipenem/cilastatin for 7 days. Furthermore, his temperature came down after discontinuing imipenem/cilastatin and receiving steroids. Body temperature increased rapidly 4 hours after intravenous readministration of imipenem/cilastatin and rapidly decreased to normal after discontinuing imipenem/cilastatin and administering steroids. Conclusion: Thorough history, blood tests, physical examination, and computed tomography (CT) did not reveal any evidence of fever. Drug fever caused by imipenem/cilastatin was considered. We also present a review of relevant literature and provide a point of reference for the clinical diagnosis and therapy of patients with drug fever.

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Section: E122mentioning

confidence: 99%

“…It is necessary to inform patients of the risk and prepare a first aid drug before taking DPT. A low-dose steroid can facilitate inflammation recession, especially when the adverse reaction is severe and fatal [Shao 2015].…”

Section: E122mentioning

confidence: 99%

Unusual Drug Fever Caused by Imipenem/Cilastatin and a Review of Literature

Yang

Wang

et al. 2019

HSF

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“…The identification of deep-seated infection foci and tumours require imaging such as ultrasonography, CT scans and magnetic resonance imaging (MRI)15. Confirmation of an ectopic cytokine-producing tumour requires the use of Enzyme Linked Immune sorbent Assay (ELISA) for granulocyte colony-stimulating factor (G-CSF), granulocyte-macrophage colony-stimulating factor GM-CSF and interleukin (IL)-6 levels16.…”

Section: Discussionmentioning

confidence: 99%

A case of a 22-month-old boy with necrotizing pneumonia presenting with leukaemoid reaction misdiagnosed as leukaemia: A case report and review of the literature

Jumanne

2019

Mal. Med. J

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BackgroundNecrotizing pneumonia and hyperleukocytosis, to the extent of that seen in leukaemia, is a rarely reported presentation. The commonest trigger of such a presentation is an inflammatory process caused by an overwhelming infection which leads to bone marrow irritation. However, the misdiagnosis of this clinical entity as leukaemia should be avoided at all costs so as to avoid the anxiety associated with a diagnosis of cancer, both to the patients and their families.Case presentationHere, we report the case of a 22-month-old boy who was referred to our Pediatric Oncology Unit (POU). Owing to a high total leukocyte count (TLC) of 98,000 cells/µl, there was a strong suspicion of leukaemia. The boy had been reviewed at another hospital where he presented with fever and cough refractory to the commencement of tuberculosis medications as a result of chest radiography findings. Laboratory investigations performed on admission in the POU were negative for leukaemia and other myeloproliferative disorders. A chest computer tomography (CT) scan was performed to delineate opacification in the right middle lobe. This revealed multiple necrotic and emphysematous foci in line with a diagnosis of necrotizing pneumonia. Subsequently, the patient responded well to a course of piperacillin- tazobactam. The TLC normalized and the cough and fever resolved over a period of 2 weeks. ConclusionHere, we describe a particularly rare case of leukaemoid reaction with a massive leukocyte count. Such patients can be easily misdiagnosed as having leukaemia or other myeloproliferative disorders, especially in settings with limited diagnostic availability. Such misdiagnosis can cause undue stress on the patient and their families. Thus, it is important that patients presenting with these symptoms should undergo a thorough review of history, physical examination and a structured workup.

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“…Prevalence of SSLR is nearly 0,2% but in children it's 0,5% and in children younger than 5 years it's 0,9% that is related to more frequent AB use in children, first of all these AB are cephaclor and ampicillin during long-term or repeated courses [11][12][13][14].…”

Section: Serum Sickness Like Reaction (Sslr)mentioning

confidence: 99%

Fever as an Adverse Drug Reaction of Different Therapeutic Groups

Postnikov¹,

Teplova²,

Ermilin³

et al. 2020

AJP

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Fever (t>38°C) developed in association with drug usage is rare but sometimes severe side effect (SE). It could manifest as single symptom or as a part of such life-threatening syndromes like malignant hyperthermia (MH), serotonin syndrome (SS), neuroleptic malignant syndrome (NMS). Fever could be caused by different therapeutic groups of drugs but the leading positions are occupied by antibiotics (mainly beta-lactams), substances acting on central nervous system (CNS) and chemotherapeutic agents. Main mechanisms are allergic and receptive. Curative measures include discontinuation of the suspected drug, introduction of agents blocking the action of the trigger factor -dantrolene (МН), bromocriptine (NMS), cyproheptadine (SS). Purpose of this review: to present the global and Russian data concerning fever as a drug-induced side effect. To distinguish the groups of patients and drugs of the highest risk. To evaluate aid measures. Results: fever as monosymptom of drug allergy is a difficult condition to be diagnosed and there are only few things that could help to recognize it such as temporal association with the suspected drug use and manifestation of fever along with the following resolution after suspected drug discontinuation and recurrence fever after suspected drug re-challenge. Among four syndromes described in this review such as serum sickness-like reaction (SSLR), NMS, SS and MH just fever at MH is not only a sign like in case of three others but it is significant and life-threatening manifestation and therefore requires additional curative methods (in addition to pharmacological support with dantrolene) -rapid cooling measures: ice-water nasogastric and rectal lavage, infusion of crystalloid solutions cooled up to 4°C, ice packs placing on main blood vessels and liver area, ventilatory measurements.

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Tigecycline-induced Drug Fever and Leukemoid Reaction

Abstract: Supplemental Digital Content is available in the text

Cited by 10 publications

References 6 publications

Unusual Drug Fever Caused by Imipenem/Cilastatin and a Review of Literature

Unusual Drug Fever Caused by Imipenem/Cilastatin and a Review of Literature

A case of a 22-month-old boy with necrotizing pneumonia presenting with leukaemoid reaction misdiagnosed as leukaemia: A case report and review of the literature

Fever as an Adverse Drug Reaction of Different Therapeutic Groups

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