Tierexperimenteller Beitrag zur Frage der Schwangerschaftsverlängerung Durch Corpus Luteum-Hormon

Ehrhardt, Karl; Kneip, P.

doi:10.1007/bf01783913

Cited by 3 publications

(1 citation statement)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The view that this concept could be applied to all eutherian mammals (Csapo, 1963) has been subject to criticism since there appear to be a number of exceptions. For example, pro¬ gesterone does not inhibit myometrial activity in the guinea-pig (Ehrhardt & Kneip, 1942; Not only is there controversy over the action of progesterone, but there have been suggestions that oestrogens may act as myometrial inhibitors. Thus Coutinho & DeMattos (1968) claim that oestradiol-17ß in 'physiological' doses suppresses uterine mechanical activity in rabbits and a similar claim has been made in women (Coutinho, 1967).…”

Section: Introductionmentioning

confidence: 97%

RAT MYOMETRIAL ACTIVITY IN VIVO: EFFECTS OF OESTRADIOL-17β AND PROGESTERONE IN RELATION TO THE CONCENTRATIONS OF CYTOPLASMIC PROGESTERONE RECEPTORS

Downing¹,

Lye²,

Bradshaw³

et al. 1978

Journal of Endocrinology

View full text Add to dashboard Cite

The amplitude, frequency and rate of rise of intra-uterine pressure cycles in rats (postpartum, ovariectomized) were unaffected by treatment with progesterone. Amplitude was also unaffected by a combination of treatments with progesterone and oestradiol-17 beta, which was adequate to ensure the survival of 84% of foetuses in ovariectomized pregnant rats. The failure of progesterone to influence myometerial activity could not be attributed to a lack of "true" progesterone receptors since these were present in the myometria of the test animals in concentrations exceeding those of oestrous animals. Evidence was obtained which suggested that a high-affinity binding protein, different from the "true" receptor may predominate in the myometrium of the pregnant rat. Oestradiol-17 beta in single or repeated doses of from 0.25 to 5 microgram, however, was found to reduce the frequency of pressure cycles but to increase significantly their rate of rise of pressure. There was a latency of 6--8 h in these effects of oestradiol. The possibility that inhibition of the myometrium by oestrogen may play a part in the preparation for parturition is discussed.

show abstract

Section: Introductionmentioning

confidence: 97%