Tierexperimentelle Untersuchungen über den Blutalkoholabbau im standardisierten hämorrhagischen Schock

Abstract

Ethanol at a dosage of 3 g/kg reduced body weight was injected i.v. into mongrel dogs resulting in a blood alcohol concentration of approximately 2.9 mg/ml. One hour after injection the dogs were anaesthetized with halothane-N20/02 and blood was withdrawn until the blood pressure was reduced to 40 mmHg. This usually required removal of about 30 - 40% of the total blood volume. The resulting haemorrhagic shock was ascertained by monitoring blood pH, pCO2, pO2, lactate, pyruvate and blood electrolytes. A blood specimen for enzymatic alcohol determination (ADH) was obtained every 30 min over a period of 3 hours. Compared with equally dosed controls the dogs in haemorrhagic shock showed a significant (p = 0.005) reduction of the blood alcohol decay rate (beta) which is explained by 1) the diminished blood flow through the liver and 2) the hypoxaemic metabolic situation in shock.

Correlation between postmortem ethanol levels in the blood and the testicle

“…This tends to confirm that the so-called acute hemorrhage does not influence the alcoholemia [11,32], whereas repeated, chronic hemorrhage accompanied by shock (e.g., due to a stomach ulcer), on the contrary, does [25]i In our B series survival was short. This tends to confirm that the so-called acute hemorrhage does not influence the alcoholemia [11,32], whereas repeated, chronic hemorrhage accompanied by shock (e.g., due to a stomach ulcer), on the contrary, does [25]i In our B series survival was short.…”

Impact of Trauma, Massive Blood Loss and Administration of Resuscitation Fluids on a Person's Blood-Alcohol Concentration and Rate of Ethanol Metabolism

“…Kaufmann et al used dogs to investigate the effect of blood loss on changes in BAC and rates of ethanol elimination (48). Animals were given ethanol (3.0 g/ kg) by intravenous infusion to reach a peak BAC of ~2.9 g/L and 60 minutes later one group (n = 8) was drained of 30-40% of their total blood volume until blood pressure dropped to 40 mmHg.…”

“…The impact of trauma and hemorrhagic shock on a preexisting BAC and rate of ethanol metabolism has been studied by forensic practitioners in Germany and the first article dates from 1937 (60). Results from experiments in animals, human volunteers and actual trauma victims undergoing life-saving emergency treatment are reviewed in the present article (46)(47)(48)(49). By contrast, there is virtually no information available in English language journals about the impact of trauma and blood loss on a person's BAC, apart from an early study in mice (61).…”

“…Mean blood-alcohol curves in dogs (n = 8 animals) given an ethanol dose of 3.0 g/kg body weight by intravenous infusion and one hour later ∼30-40% of blood volume was removed from an indwelling catheter resulting in hypovolemic shock. Graph modified and redrawn from reference (48). …”

“…Mean blood-alcohol curves in dogs (n = 8 animals) given an ethanol dose of 3.0 g/kg body weight by intravenous infusion and one hour later ~30-40% of blood volume was removed from an indwelling catheter resulting in hypovolemic shock. Graph modified and redrawn from reference(48). , Blood-Loss and Blood-Alcohol Concentration ACADEMIC FORENSIC PATHOLOGY: THE OFFICIAL PUBLICATION OF THE NATIONAL ASSOCIATION OF MEDICAL EXAMINERS ©2016 Academic Forensic Pathology IncorporatedDownloaded from www.afpjournal.com by an AFP Journal subscriber This article is for personal use only and may not be shared or distributed in any fashion…”