Tier, Tiere

Becker, Siegfried

doi:10.1515/emo.13.123

Cited by 1 publication

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“…Physical activity was categorized into sLx levels: from high to low. Calcium intake was estimated from the reported intake of dairy products [17]. On the basis of the second Swedish National Nutritional Survey performed 1997-1998 by the National Food Administration, it has been calculated that around 73% of calcium intake is consumed as milk and cheese.…”

Section: Clinical Variablesmentioning

confidence: 99%

Multifactorial risk profile for bone fractures in primary hyperparathyroidism

et al. 2002

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Primary hyperparathyroidism (pHPT) is associated with an increased fracture risk, and decreased bone density thus has been considered an indication for surgery. However, many pHPT patients have a multifactorial risk profile for osteoporosis and bone fractures. The aim of the present study was to evaluate variables associated with fracture risk within the group of pHPT patients. A series of 203 consecutive patients operated for pHPT were investigated with bone mineral content and biochemical and clinical risk factors for bone fracture. Seventeen patients (8%) had a history of at least one bone fracture up to 5 years before pHPT surgery. Twenty-six patients (13%) had a history of at least one fracture during the 10-year period prior to surgery. In the univariate analyses corticosteroid treatment, serum levels of alkaline phosphatase, 25-hydroxyvitamin D3, type I collagen telopeptide, and bone mineral content were found to be associated with a history of bone fractures up to 10 years before surgery. Additionally, age and menopausal status were of importance for fractures during the 10-year-period, whereas a history of cardiovascular disease was important for fractures during the 5-year-period prior to surgery. Multivariate analyses showed that serum level of PTH was independently associated with bone fractures during the 5-year period prior to pHPT surgery and further that serum level of 25-hydroxyvitamin D3 was associated with fractures up to 10 years before surgery. In conclusion, serum levels of 25-hydroxyvitamin D3 and PTH were independently associated with a history of bone fractures in pHPT. These variables should be considered when evaluating patients for parathyroid surgery.

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Section: Clinical Variablesmentioning

confidence: 99%