Tieguanyin extracts ameliorated DSS-induced mouse colitis by suppressing inflammation and regulating intestinal microbiota

Abstract

Previous studies have shown that a typical kind of oolong tea Tieguanyin has multiple health benefits, while there is no research investigating its effects on inflammatory bowel diseases (IBD). In...

Stored white tea ameliorates DSS-induced ulcerative colitis in mice by modulating the composition of the gut microbiota and intestinal metabolites

“…These results are consistent with reports that the administration of fuzhuan brick tea significantly inhibited the relative abundance of both g_Bacteroides and g_Escherichia-Shigella , and the intake of Tieguanyin oolong tea reduced the abundance of g_Escherichia-Shigella by about 20%. 38,39 There were no significant differences in the abundance of g_Parabacteroides (Fig. 3L) or g_Candidatus Saccharimonas in the 5-ASA-, 2021 WP-, and 2011 WP-treated groups compared with that in the DSS group (Fig.…”

Urolithin A Alleviates Colitis in Mice by Improving Gut Microbiota Dysbiosis, Modulating Microbial Tryptophan Metabolism, and Triggering AhR Activation

“…35 Therefore, IL-10 is regarded as a blocker of pro-inflammatory responses in many colitis models in response to polysaccharide, polyphenol, and peptide treatments. 36 However, in some other studies, serum IL-10 was increased in response to DSS treatment, suggesting an opposite indicator to show the severity of colitis in mice, 3 indicating the more complex function of IL-10 in IBD; these findings explain the results that IBD patients display no significant benefit from treatment with recombinant IL-10 and PEGylated fusion proteins. 37 In addition, the majority of IL-22-associated molecules are encoded by IBD susceptibility genes, indicating the vital role of IL-22.…”

“…Previous studies reported the strong relationship of IL-10 to IBD pathogenesis through genome-wide association studies, and direct causal evidence was obtained in IL-10 –/– mice with spontaneous development of enterocolitis . Therefore, IL-10 is regarded as a blocker of pro-inflammatory responses in many colitis models in response to polysaccharide, polyphenol, and peptide treatments . However, in some other studies, serum IL-10 was increased in response to DSS treatment, suggesting an opposite indicator to show the severity of colitis in mice, indicating the more complex function of IL-10 in IBD; these findings explain the results that IBD patients display no significant benefit from treatment with recombinant IL-10 and PEGylated fusion proteins .…”

Grape seed proanthocyanidin extract alleviates inflammation in experimental colitis mice by inhibiting NF‐κB signaling pathway

“…GSPE (50 and 100 mg/kg) significantly reversed the shortening of colonic tissue compared with the DSS model group (Figure 2A,B). The degree of spleen enlargement may be positively related to the degree of the inflammation in colon tissues and the intestinal hemorrhage, also treated as an indirect indicator of the severity of UC 24 . It could be observed that mice in the DSS modeling group had markedly enlarged spleen size and weight, accompanied by a certain degree of inflammatory changes.…”

“…The degree of spleen enlargement may be positively related to the degree of the inflammation in colon tissues and the intestinal hemorrhage, also treated as an indirect indicator of the severity of UC. 24…”