Tie-mediated signal from apoptotic cells protects stem cells in Drosophila melanogaster

Xing, Yalan; Su, Tin Tin; Ruohola‐Baker, Hannele

doi:10.1038/ncomms8058

Cited by 54 publications

(90 citation statements)

References 58 publications

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“…Although aged stem cells have been shown to accumulate DNA damage, it remains largely unclear how DNA damage affects stem cell self-renewal and differentiation. A previous study has reported that upon weak irradiation apoptotic differentiated GSC progeny can prevent GSC loss by activating Tie-2 receptor tyrosine kinase signaling (Xing et al, 2015). In this study, we show that temporally introduced DNA double-stranded breaks cause premature GSC loss and slow down GSC progeny differentiation (Fig.…”

Section: Discussionsupporting

confidence: 62%

DNA damage-induced Lok/CHK2 activation compromises germline stem cell self-renewal and lineage differentiation

Han

Song

et al. 2016

Development

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Stem cells in adult tissues are constantly exposed to genotoxic stress and also accumulate DNA damage with age. However, it remains largely unknown how DNA damage affects both stem cell selfrenewal and differentiation. In this study, we show that DNA damage retards germline stem cell (GSC) self-renewal and progeny differentiation in a Lok kinase-dependent manner in the Drosophila ovary. Both heatshock-inducible endonuclease I-CreI expression and X-ray irradiation can efficiently introduce double-strand breaks in GSCs and their progeny, resulting in a rapid GSC loss and a GSC progeny differentiation defect. Surprisingly, the elimination of Lok or its kinase activity can almost fully rescue the GSC loss and the progeny differentiation defect caused by DNA damage induced by I-CreI or X-ray. In addition, the reduction in bone morphogenetic protein signaling and Shotgun expression only makes a limited contribution to DNA damage-induced GSC loss. Finally, DNA damage also decreases the expression of the master differentiation factor Bam in a Lok-dependent manner, which helps explain the GSC progeny differentiation defect. Therefore, this study demonstrates, for the first time in vivo, that Lok kinase activation is required for the DNA damage-mediated disruption of adult stem cell self-renewal and lineage differentiation, and might also offer novel insight into how DNA damage causes tissue aging and cancer formation.

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Section: Discussionsupporting

confidence: 62%

DNA damage-induced Lok/CHK2 activation compromises germline stem cell self-renewal and lineage differentiation

Han

Song

et al. 2016

Development

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“…Random lasers123 (RLs) are a special class of lasers with Lévy-type distributions of intensity fluctuations45678910111213, which has been recently exploited as a photonic platform for studies of complex systems, such as spin glasses141516171819202122. RLs were originally proposed23 by Letokhov in the late 1960’s, but their first unambiguous observation was only reported in 1994 by Lawandy and collaborators24.…”

mentioning

confidence: 99%

“…In the photonic context, the term spin glass (SG) means that intensity spectra emitted under identical experimental conditions keep a complex pattern of correlations1516171819202122, as quantified below. Moreover, the Lévy statistics implies strong fluctuations in the emission intensity, with non-Gaussian heavy-tailed distribution45678910111213.…”

mentioning

confidence: 99%

Observation of Lévy distribution and replica symmetry breaking in random lasers from a single set of measurements

Gomes¹,

Raposo²,

Moura³

et al. 2016

Sci Rep

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Random lasers have been recently exploited as a photonic platform for studies of complex systems. This cross-disciplinary approach opened up new important avenues for the understanding of random-laser behavior, including Lévy-type distributions of strong intensity fluctuations and phase transitions to a photonic spin-glass phase. In this work, we employ the Nd:YBO random laser system to unveil, from a single set of measurements, the physical origin of the complex correspondence between the Lévy fluctuation regime and the replica-symmetry-breaking transition to the spin-glass phase. A novel unexpected finding is also reported: the trend to suppress the spin-glass behavior for high excitation pulse energies. The present description from first principles of this correspondence unfolds new possibilities to characterize other random lasers, such as random fiber lasers, nanolasers and small lasers, which include plasmonic-based, photonic-crystal and bio-derived nanodevices. The statistical nature of the emission provided by random lasers can also impact on their prominent use as sources for speckle-free laser imaging, which nowadays represents one of the most promising applications of random lasers, with expected progress even in cancer research.

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“…It has been previously reported that dividing germline cystocytes undergo a Caspase-dependent cell death in response to metabolic stresses (Drummond-Barbosa and Ikeya et al, 2002;Morrison and Spradling, 2008). Activated Caspase labeling of GSCs was surprising, however, given that it has been reported that GSCs and other stem cells are resistant to apoptosis after irradiation (Xing et al, 2015). It is possible that mitochondrial stress is a more potent inducer of apoptosis in stem cells than the genotoxic stress caused by irradiation.…”

Section: Discussionmentioning

confidence: 99%

Incompatibility between mitochondrial and nuclear genomes during oogenesis results in ovarian failure and embryonic lethality

2017

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Mitochondrial dysfunction can cause female infertility. An important unresolved issue is the extent to which incompatibility between mitochondrial and nuclear genomes contributes to female infertility. It has previously been shown that a mitochondrial haplotype from D. simulans (simw 501) is incompatible with a nuclear genome from the D. melanogaster strain Oregon-R (OreR), resulting in impaired development, which was enhanced at higher temperature. This mitonuclear incompatibility is between alleles of the nuclear-encoded mitochondrial tyrosyl-tRNA synthetase (Aatm) and the mitochondrialencoded tyrosyl-tRNA that it aminoacylates. Here, we show that this mito-nuclear incompatibility causes a severe temperature-sensitive female infertility. The OreR nuclear genome contributed to death of ovarian germline stem cells and reduced egg production, which was further enhanced by the incompatibility with simw 501 mitochondria. Mito-nuclear incompatibility also resulted in aberrant egg morphology and a maternal-effect on embryonic chromosome segregation and survival, which was completely dependent on the temperature and mito-nuclear genotype of the mother. Our findings show that maternal mito-nuclear incompatibility during Drosophila oogenesis has severe consequences for egg production and embryonic survival, with important broader relevance to human female infertility and mitochondrial replacement therapy.

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Tie-mediated signal from apoptotic cells protects stem cells in Drosophila melanogaster

Cited by 54 publications

References 58 publications

DNA damage-induced Lok/CHK2 activation compromises germline stem cell self-renewal and lineage differentiation

DNA damage-induced Lok/CHK2 activation compromises germline stem cell self-renewal and lineage differentiation

Observation of Lévy distribution and replica symmetry breaking in random lasers from a single set of measurements

Incompatibility between mitochondrial and nuclear genomes during oogenesis results in ovarian failure and embryonic lethality

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