Tidal disruption events (TDEs), in which stars are gravitationally disrupted as they pass close to the supermassive black holes in the centres of galaxies 1 , are potentially important probes of strong gravity and accretion physics. Most TDEs have been discovered in large-area monitoring surveys of many 1000s of galaxies, and the rate deduced for such events is relatively low: one event every 10 4 -10 5 years per galaxy 2-4 . However, given the selection effects inherent in such surveys, considerable uncertainties remain about the conditions that favour TDEs. Here we report the detection of unusually strong and broad helium emission lines following a luminous optical flare (M v <-20.1 mag) in the nucleus of the nearby ultra-luminous infrared galaxy F01004-2237. The particular combination of variability and post-flare emission line spectrum observed in F01004-2237 is unlike any known supernova or active galactic nucleus. Therefore, the most plausible explanation for this phenomenon is a TDE-the first detected in a galaxy with an ongoing massive starburst. The fact that this event has been detected in repeat spectroscopic observations of a sample of 15 ultra-luminous infrared galaxies over a period of just 10 years suggests that the rate of TDEs is much higher in such objects than in the general galaxy population.Ultra-luminous infrared galaxies (ULIRGs: L IR > 10 12 L ¤ ) 5 represent the peaks of major, gas-rich galaxy mergers in which the merger-induced gas flows concentrate the gas into the nuclear regions, leading to high rates of star formation and accretion onto the central supermassive black holes. The nearby ULIRG F01004-2237 (RA: 01h 02m 50.007s and Dec: -22d 21m 57.22s (J2000); z=0.117835) was observed using deep spectroscopic observations in September 2015 as part of a study of 15 ULIRGs to examine the importance of the warm gas outflows driven by active galactic nuclei (AGNs) in such objects 6 . Many of its properties are typical of local ULIRGs, including relatively modest total stellar and supermassive black hole masses, and evidence for AGN activity in the form of blue-shifted high ionization emission lines 6 . However, it is unusual in the sense that it is one of the few ULIRGs in which Wolf-Rayet features have been detected at optical wavelengths 9 , indicating the presence of a population of ~3×10 4 Wolf-Rayet stars with ages 3-6 Myr (supplementary information). Also, unlike most ULIRGs for which the central starburst regions are heavily enshrouded in dust, this source has a compact nucleus that is barely resolved in optical and UV observations with the Hubble Space Telescope (HST) and has been attributed to a population of stars that is both young ( < 10 Myr) and massive (~3×10 8 M ¤ ) 10 . Together, these features suggest that we have an unusually clear view of the nuclear star forming regions in F01004-2237. However, the 2015 spectra are markedly different: the ~4660Å feature is a factor of 5.6+/-1.1 stronger in flux compared with 2000, and the blend has developed broad wings that extend up to...