Tidal breathing parameters in the first week of life and subsequent cough and wheeze.

Yüksel, B.; Greenough, Anne; Giffin, F.; Nicolaides, Kypros H.

doi:10.1136/thx.51.8.815

Cited by 33 publications

(29 citation statements)

References 17 publications

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“…A low value of t PTEF / t E as a risk factor for OAD as found in the present study supports previous reports (7,19). However, the odds ratio of 3.5 for t PTEF / t E in the present study is substantially lower than the reported odds ratio of 10.1 for OAD by the Tucson group (7), but more in keeping with the results of Yuksel et al.…”

Section: Discussionsupporting

confidence: 93%

Perinatal risk factors for recurrent wheeze in early life

Carlsen

Carlsen²,

Nafstad³

et al. 1999

Pediatric Allergy Immunology

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The possible value of tidal flow volume (TFV) loops measured at birth in relation to the risk of developing recurrent or persistent bronchial obstruction within two years of life was assessed. TFV loops were measured at a mean age of 2.7 days in 802 neonates enrolled in the 'Environment and Childhood Asthma' (ECA) study in Oslo. Of these, 77 children developed recurrent or persistent bronchial obstruction (cases) and were included in a nested case-control study within the ECA study; 88 controls (the child born closest in time to the case), with no history of bronchial obstruction in the first two years of life, were also included. Information on socio-economic factors, parental atopic diseases and parental smoking habits during the pregnancy was collected from a questionnaire completed by the parents in the maternity ward, and cord blood IgE (CB-IgE) was determined as part of routine sampling in the delivery ward. Mean tPTEF/tE (time to reach peak flow to total expiratory time) was slightly lower in cases (0.31; 95% CI 0.28-0.34) than in controls (0.33; 0.31-0.35) (difference not significant), whereas geometric mean CB-IgE was significantly higher among cases (0.39; 0.30-0.52) than controls (0.27; 0.23-0.33). No significant differences between cases and controls were found for respiratory rate, peak tidal expiratory flow or expiratory volume. However, the odds ratio for developing recurrent or persistent bronchial obstruction was 3.5 (1.1-11.6) if tPTEF/tE was < 0.20 and 4.1 (1.1-14.5) with maternal daily smoking during the pregnancy, after adjusting for age, weight, sex, CB-IgE, parental atopy, maternal education and family income. The TFV parameter tpTEF/tE < 0.20 measured within the first week of life as well as maternal daily smoking during pregnancy are significant, independent risk factors for developing recurrent or persistent bronchial obstruction within the first two years of life.

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Section: Discussionsupporting

confidence: 93%

Perinatal risk factors for recurrent wheeze in early life

Carlsen

Carlsen²,

Nafstad³

et al. 1999

Pediatric Allergy Immunology

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“…mean VT 24.8 mL and mean tPTEF/tE 32.0%) and one by STOCKS et al [34] assessing lung function in 23 full-term unsedated infants of equivalent age (mean VT 36.1 mL and mean tPTEF/tE 32.5%). Our data also compares favourably with studies assessing the tPTEF/tE, supporting the idea of a slowly decreasing tPTEF/tE during the first year of life, although these studies use several techniques with and without sedation over a wide age range [35].…”

Section: Limitations and Open Questionssupporting

confidence: 78%

Normative data for lung function and exhaled nitric oxide in unsedated healthy infants

Fuchs¹,

Latzin²,

Thamrin³

et al. 2010

Eur Respir J

123

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Despite association with lung growth and long-term respiratory morbidity, there is a lack of normative lung function data for unsedated infants conforming to latest European Respiratory Society/American Thoracic Society standards.Lung function was measured using an ultrasonic flow meter in 342 unsedated, healthy, termborn infants at a mean¡SD age of 5.1¡0.8 weeks during natural sleep according to the latest standards. Tidal breathing flow-volume loops (TBFVL) and exhaled nitric oxide (eNO) measurements were obtained from 100 regular breaths. We aimed for three acceptable measurements for multiple-breath washout and 5-10 acceptable interruption resistance (Rint) measurements.Acceptable ) for Rint. In males, TBFVL outcomes were associated with anthropometric parameters and in females, with maternal smoking during pregnancy, maternal asthma and Caesarean section.This large normative data set in unsedated infants offers reference values for future research and particularly for studies where sedation may put infants at risk. Furthermore, it highlights the impact of maternal and environmental risk factors on neonatal lung function.

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“…The findings of previously published studies have been inconsistent in this respect, with some reporting a reduction (13,27), but others no difference (28,29), in premorbid measures of t PTEF :t E among those with subsequent wheezing. The extent to which this parameter reflects airway function remains controversial (1,30,31).…”

Section: Interpretation Of Respiratory Function Testsmentioning

confidence: 86%

Impaired Airway Function and Wheezing in Infancy

Dezateux¹,

Stocks²,

Dundas³

et al. 1999

Am J Respir Crit Care Med

211

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This prospective community-based study of infants born in inner London was undertaken to examine the association between premorbid airway function and subsequent wheezing in the first year of life and to explore the influence on this association of a family history of asthma and maternal smoking during pregnancy. Healthy Caucasian term infants were recruited shortly after birth, and physician-diagnosed wheezing episodes were identified retrospectively from medical records. Specific airway conductance was determined from plethysmographic measurements of lung volume and airway resistance, before 13 wk and prior to any respiratory illness, in 101 infants, 28 of whom experienced at least one episode of wheezing during the first year. Mean (SD) specific airway conductance was significantly diminished in infants who subsequently wheezed: 2.02 (1.07) s-1. kPa-1 and 2.60 (0.93) s-1. kPa-1, respectively (p < 0.05), and in those with a first-degree relative with asthma: 1.98 (0.83) s-1. kPa-1 and 2.60 (1.0) s-1. kPa-1, respectively (p < 0.05), but not in those whose mothers smoked during pregnancy, in whom airway resistance was, however, significantly elevated (p < 0.05). The odds ratio (95% confidence interval [CI]) for wheezing was 2.1 (1.1 to 3.8) for every unit (s-1. kPa-1) decline in specific airway conductance (p = 0.02). After adjustment for premorbid airway function, the odds of wheezing were significantly increased in those with a family history of asthma (4. 3; 95% CI, 1.3 to 13.8; p = 0.016) and those exposed to maternal smoking during pregnancy (4.9; 95% CI, 1.6 to 15.0; p = 0.005). Our findings confirm previous reports that impaired premorbid airway function precedes and predicts wheezing in the first year. Among those with a genetic predisposition to asthma, alterations in airway geometry or tone may increase susceptibility to wheezing. Maternal smoking has important and potentially preventable adverse effects on somatic growth and respiratory morbidity in early life.

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Tidal breathing parameters in the first week of life and subsequent cough and wheeze.

Cited by 33 publications

References 17 publications

Perinatal risk factors for recurrent wheeze in early life

Perinatal risk factors for recurrent wheeze in early life

Normative data for lung function and exhaled nitric oxide in unsedated healthy infants

Impaired Airway Function and Wheezing in Infancy

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