Tickborne encephalitis despite specific immunoglobulin prophylaxis

Kluger, Gerhard; Schöttler, A.; Waldvogel, Katharina; Nadal, David; Hinrichs, Wouter L. J.; Wündisch, G. F.; Laub, M.C.

doi:10.1016/s0140-6736(95)92527-9

Cited by 68 publications

(27 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Alternatively, low levels of neutralizing flavivirus crossreactive antibodies can result in an increased severity of secondary flavivirus infections due to a phenomenon called antibody-dependent enhancement, particularly after infection with dengue virus [13]. In TBE, disease exacerbations were reported after passive immunization [14,15] and this and other reports have shown a notably severe course after active vaccination [9,10,12]; however, current laboratory data do not support the concept of antibody-dependent enhancement for human TBE [16].…”

Section: Discussionmentioning

confidence: 74%

Delayed Humoral Immunity in a Patient with Severe Tick-borne Encephalitis after Complete Active Vaccination

et al. 2007

View full text Add to dashboard Cite

Tick-borne encephalitis virus (TBEV) is a common cause of viral encephalitis in parts of Central and Eastern Europe. Active immunization results in a high rate of seroconversion and is the most effective measure of decreasing the incidence of tick-borne encephalitis (TBE). Currently, booster vaccinations are recommended every 3 years after completion of primary immunization. However, titers of neutralizing antibodies decline with time after vaccination and with age and thus may be insufficient to protect from disease in the elderly. We report on a 54-year-old patient who had received his last booster vaccination 3 years before developing a severe TBE with delayed induction and longterm persistence of anti-TBEV-IgM-antibodies.

show abstract

Section: Discussionmentioning

confidence: 74%

Delayed Humoral Immunity in a Patient with Severe Tick-borne Encephalitis after Complete Active Vaccination

et al. 2007

View full text Add to dashboard Cite

show abstract

“…Cross-enhancing activity has been shown to occur among MVE, JE, and West Nile viruses in chick embryo fibroblast cell lines [Hawkes, 1964;Hawkes and Lafferty, 1967] while enhancement of Yellow fever and JE virus infections in mice by monoclonal antibodies reacting to the E protein of these viruses has also been demonstrated Gould and Buckley, 1989]. In addition, Kluger et al, [1995] have reported anecdotal evidence of possible enhancement of Tickborne encephalitis infection in humans after passive immunisation with specific Ig. However, these results were not supported by subsequent studies in mice [Kreil and Eibl., 1997].…”

Section: Discussionmentioning

confidence: 99%

Immunisation with gamma globulin to Murray Valley encephalitis virus and with an inactivated Japanese encephalitis virus vaccine as prophylaxis against Australian encephalitis: Evaluation in a mouse model

et al. 2000

View full text Add to dashboard Cite

In northwestern Australia, the flavivirus Murray Valley encephalitis (MVE) poses a significant health risk to infants in some aboriginal communities, particularly during each wet season. While there are too few cases to warrant the development of a vaccine against MVE, a safe, effective prophylaxis for these children is still urgently required. The use of passive transfer of human gamma globulin to MVE or immunisation with a vaccine to the closely related Japanese encephalitis (JE) virus were investigated as potential strategies. When 40 microg of IgG was purified from MVE-immune human sera and transferred to 3-week-old mice, the animals were protected from lethal IP inoculation with MVE virus while still producing a detectable immune response to the virus. Similarly, sera from adult mice infected sublethally with MVE or JE virus provided significant protection against MVE infection. However, sera from mice sublethally infected with the related Kunjin or immunised with the inactivated JE vaccine (Biken) provided no protection against MVE challenge. In fact, mice immunised passively with the latter appeared to succumb to MVE challenge more rapidly than mice that received serum from unimmunised animals, suggesting that antibody to the vaccine had accelerated the progression of disease. These preliminary trials in mice indicate that passive immunisation with human gamma globulin has the greatest potential as a strategy for MVE prophylaxis, whilst the apparent enhancement of MVE by antibodies to the JE vaccine requires further investigation, with particular reference to current vaccination programs in areas of Australia and Papua New Guinea, where both JE and MVE occur.

show abstract

“…Another area of controversy surrounding passive immunization for TBE is related to antibody-dependent enhancement (ADE). Several case reports suggest that the disease is exacerbated by postexposure passive immunization (Kluger et al, 1995;Arras et al, 1996;Waldvogel et al, 1996). However, other studies demonstrated that in vivo enhancement of TBEV infection by TBEV antibodies could not be observed although those antibodies were able to induce ADE in mouse macrophages in vitro (Kreil and Eibl, 1997).…”

Section: Tick-borne Encephalitis Virusmentioning

confidence: 99%