Tick-Borne Viruses and Host Skin Interface

Kazimírová, Mária; Bartíková, Pavlína; Štibrániová, Iveta

doi:10.1016/b978-0-12-811436-0.00010-1

Cited by 2 publications

(2 citation statements)

References 239 publications

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“…Tick-borne viruses are causative agents of several important human diseases. Since the discovery of the first tick-borne pathogenic virus which was identified as being responsible for severe encephalitis in sheep in 1918 [41], diversified TBVs with global distribution have been discovered and isolated belonging to at least 2 orders, 9 families, and 12 genera [42]. Most of them belong to orders Bunyavirales and Mononegavirales and families of Flaviviridae, Asfarviridae, Reoviridae, and Orthomyxoviridae [43].…”

Section: Ticks and Tick-borne Pathogensmentioning

confidence: 99%

“…In recent years, the rapid development of next generation sequencing (NGS) has boosted the discovery of novel TBVs, many of them still unassigned to families (reviewed by [44]). At present, more than 16 specific tick-borne diseases (TBDs) of humans and 19 TBDs of veterinary importance have been described [42,45]. The tick-borne encephalitis virus (TBEV) is the most medically prominent and important arbovirus (arthropod-borne virus) in Europe and Northern Asia, causing more than 10,000 clinical cases of tick-borne encephalitis annually.…”

Section: Ticks and Tick-borne Pathogensmentioning

confidence: 99%

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Murine Gammaherpesvirus 68 (MHV-68), a Newly Discovered Tick Borne Virus

Kúdelová¹,

Štibrániová²

2019

Ticks and Tick-Borne Pathogens

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MHV-68, closely related to human gammaherpesviruses (Epstein-Barr virus and Kaposi's sarcoma herpesvirus), is a natural pathogen of murid rodents commonly infested with ticks. After the first finding of MHV-68 in immature Ixodes ricinus ticks removed from wild green lizards, its occurrence was proved in free-living Dermacentor reticulatus, I. ricinus, and Haemaphysalis concinna ticks. Next, finding of live MHV-68 in salivary glands, intestine, and ovaries of D. reticulatus ticks strongly supported the idea that MHV-68 could be transmitted from infected to uninfected host via blood-feeding ticks. Recently, experimental transmission of MHV-68 between I. ricinus ticks and mouse and vice versa proved that MHV-68 could be vertically and horizontally transmitted from F0 to F1 tick generation, and thus, MHV-68 is a tick-borne virus (arbovirus). Therefore, ticks commonly attack humans transmitting important pathogens (e.g., tick-borne encephalitis virus and the Lyme disease spirochete); there is the speculation that MHV-68 can also infect humans via ticks. Earlier studies documented antibodies to MHV-68 in the sera of laboratory workers, hunters, and general population as well. In future, we need to carefully test whether people bitten by ticks are at real risk of infection with MHV-68 that normally infects murid rodents, and what effect it may have.

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Section: Ticks and Tick-borne Pathogensmentioning

confidence: 99%

Section: Ticks and Tick-borne Pathogensmentioning

confidence: 99%

Murine Gammaherpesvirus 68 (MHV-68), a Newly Discovered Tick Borne Virus

Kúdelová¹,

Štibrániová²

2019

Ticks and Tick-Borne Pathogens

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Rôle immunomodulateur de la salive de tique dans la transmission d’agents infectieux

Boulanger

2018

Biologie Aujourd'hui

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Les tiques sont les vecteurs les plus importants de pathologies en médecine humaine et vétérinaire. Acariens strictement hématophages, ils produisent une salive riche en molécules bioactives qui ciblent la pharmacologie et l’immunité de l’hôte. Ce processus est absolument vital pour elles, car les tiques dures prennent des repas sanguins de plusieurs jours et doivent éviter leur rejet par l’hôte. Tous les acteurs de l’immunité sont ciblés par cette salive : l’immunité innée en lien avec les cellules résidentes de la peau et les cellules immunitaires et l’immunité adaptative liée aux lymphocytes T et B. La peau constitue donc un site particulier dans les maladies à transmission vectorielle. Au cours de leur longue co-évolution avec les tiques, les agents infectieux prennent avantage de cet environnement favorable pour être transmis efficacement dans la peau et se multiplier, pour ensuite se développer chez les hôtes vertébrés. La salive constitue pour ces microorganismes un véritable facteur de virulence qui augmente fortement leur pathogénicité.

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Tick-Borne Viruses and Host Skin Interface

Cited by 2 publications

References 239 publications

Murine Gammaherpesvirus 68 (MHV-68), a Newly Discovered Tick Borne Virus

Murine Gammaherpesvirus 68 (MHV-68), a Newly Discovered Tick Borne Virus

Rôle immunomodulateur de la salive de tique dans la transmission d’agents infectieux

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