Tick-borne viruses: A review from the perspective of therapeutic approaches

Lani, Rafidah; Moghaddam, Ehsan; Haghani, Amin; Chang, Li-Yen; AbuBakar, Sazaly; Zandi, Keivan

doi:10.1016/j.ttbdis.2014.04.001

Cited by 66 publications

(64 citation statements)

References 112 publications

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“…U n C o r r e c t e d P r o o f designed and used for human use (45). In addition, the identification of pathogen transmission mechanisms in ticks may provide the opportunity to disrupt transmission routes and may contribute to the development of vaccines against tick-borne diseases (46) including strains of CCHFV that circulate in Iran.…”

Section: Discussionmentioning

confidence: 99%

Spatial and Phylodynamic Survey on Crimean-Congo Hemorrhagic Fever Virus Strains in Northeast of Iran

Faghihi

Telmadarraiy

Chinikar

et al. 2018

Jundishapur J Microbiol

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Background: Crimean-Congo hemorrhagic fever (CCHF) is asymptomatic in infected animals, yet the virus poses a serious threat to humans causing a symptomatic, hemorrhagic disease with a high case-fatality rate. Numerous genera of ticks serve as both vectors and reservoirs of the Crimean-Congo hemorrhagic fever virus (CCHFV). Objectives:The aim of the present study is to determine the CCHFV prevalence in ticks from northeast Iran to establish a phylogenetic relationship of the tick-derived CCHFV strains circulating in Iran.Methods: During April to June 2013, a total of 93 hard ticks were collected from different animals in the Damghan district. The Ssegment of positive samples was fully sequenced using the Sanger technique. A total of 142 CCHFV sequences comprised full-length of CCHFV sequences obtained in this study were aligned using the MAFFT algorithm, then phylogenetic tree was constructed using Geneious v 7.1.8. Results:The identified tick species included Hyalomma marginatum (6.5%), Hy. dromedarii (21.5%), Hy. anatolicum (15.1%), Hy. asiaticum (3.2%) and Hy. schulzei (2.2%), as well as Rhipicephalus sanguineus (47.3%). The CCHFV RNA was detected in 4 samples of 93 tick samples (4.3%) by RT-PCR. A total of 4 CCHFV sequences were obtained in this study clustered within clade IV (Asia-1 and Asia-2). Conclusions:We demonstrated that 4 species of hard ticks could be a vector for CCHFV in Iran. In addition, our findings indicate the circulation of CCHFV clade IV strain in the northeast of Iran and provide a solid base for more targeted surveillance and prevention programs in Iran.

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Section: Discussionmentioning

confidence: 99%

Spatial and Phylodynamic Survey on Crimean-Congo Hemorrhagic Fever Virus Strains in Northeast of Iran

Faghihi

Telmadarraiy

Chinikar

et al. 2018

Jundishapur J Microbiol

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“…TBE is an important cause of infection among travelers that excursion to endemic regions between April and November. Hikers and campers are at a greater risk in forested areas at altitudes of about 1500 m. 39,40 Baltic States, the Russian Federation, and Slovenia are known to have a high incidence of TBE. 40 Outdoor recreation activities and wearing short trousers in areas of long grass are major risk factors in endemic georaphical areas.…”

Section: Viral Infections Arbovirus Infectionsmentioning

confidence: 99%

Unexpected Risks for Campers and Hikers: Tick-Borne Infections

Dinç

Demiraslan

Doğanay

2017

Int J Travel Med Glob Health

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“…Bununla birlikte gerekli infeksiyon kontrol tedbirleri sağlık kuruluş-larında alınmalıdır. AHFV gibi zoonotik hastalıkla-rın kontrolü için halk sağlığı uzmanı, klinisyenler, veteriner hekimler ve diğer araştırmacılar arasında işbirliği yapılması önemlidir [30] . Tedavide etkin antiviral ilaçlar olmadığından ve ekonomik açıdan değerli hayvanlar ve insanlarda hastalığı önlemek için etkin tarama ve aşı geliştirilmesine ihtiyaç duyulmaktadır [7] .…”

Section: Tedavi̇ Ve Kontrolunclassified