“…The E. chaffeensis and E. ewingii species are most common in the Southeast and South Central United States, while the E. muris species is most commonly identified in Wisconsin and Minnesota. 1,10 Definitive diagnosis is made with serologic tests, particularly the IFA, to detect the significant increases in immunoglobulin G and immunoglobulin M. 1 Treatment. Clinical manifestations differ from patient to patient, but generally include fever, headache, chills, malaise, myalgia, nausea, vomiting, diarrhea, confusion, arthralgia, and conjunctival injection.…”