Tick-borne diseases and autoimmunity: A comprehensive review

Rodríguez, Yhojan; Rojas, Manuel; Gershwin, M. Eric; Anaya, Juan Manuel

doi:10.1016/j.jaut.2017.11.007

Cited by 15 publications

(12 citation statements)

References 293 publications

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“…TBEV is one of the most important tick-transmitted zoonotic pathogens [56] and can lead to severe meningoencephalitis in humans [15]. The virus is endemic in forest and grassland areas, where it is transmitted to a multitude of animal species.…”

Section: Discussionmentioning

confidence: 99%

In Vivo Characterization of Tick-Borne Encephalitis Virus in Bank Voles (Myodes glareolus)

Michelitsch

Tews

Klaus

et al. 2019

Viruses

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Tick-borne encephalitis is the most important tick-transmitted zoonotic virus infection in Eurasia, causing severe neurological symptoms in humans. The causative agent, the tick-borne encephalitis virus (TBEV), circulates between ticks and a variety of mammalian hosts. To study the interaction between TBEV and one of its suspected reservoir hosts, bank voles of the Western evolutionary lineage were inoculated subcutaneously with either one of eight TBEV strains or the related attenuated Langat virus, and were euthanized after 28 days. In addition, a subset of four strains was characterized in bank voles of the Carpathian linage. Six bank voles were inoculated per strain, and were housed together in groups of three with one uninfected in-contact animal each. Generally, most bank voles did not show any clinical signs over the course of infection. However, one infected bank vole died and three had to be euthanized prematurely, all of which had been inoculated with the identical TBEV strain (Battaune 17-H9, isolated in 2017 in Germany from a bank vole). All inoculated animals seroconverted, while none of the in-contact animals did. Viral RNA was detected via real-time RT-PCR in the whole blood samples of 31 out of 74 inoculated and surviving bank voles. The corresponding serum sample remained PCR-negative in nearly all cases (29/31). In addition, brain and/or spine samples tested positive in 11 cases, mostly correlating with a positive whole blood sample. Our findings suggest a good adaption of TBEV to bank voles, combining in most cases a low virulence phenotype with detectable virus replication and hinting at a reservoir host function of bank voles for TBEV.

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Section: Discussionmentioning

confidence: 99%

In Vivo Characterization of Tick-Borne Encephalitis Virus in Bank Voles (Myodes glareolus)

Michelitsch

Tews

Klaus

et al. 2019

Viruses

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Section: Future Preventive Toolsmentioning

confidence: 99%

“…21,35,36 Apart from the common strategies for tick-bite prevention mentioned above, the development of tick-antigen-based vaccines could not only protect against AGS but also against other tickborne diseases. 14 Therefore, to follow the vaccinomics approach, it is essential to identify tick bioactive molecules and consequent signaling pathways that mediate tick-host-pathogen interactions. 137,138 For example, in a study by Mateos-Hernández et al, 47 tick sialome proteins, with or without α-Gal modifications, that led to a protective immune response and were recognized by AGS patients but not control individuals could serve as potential target antigen candidates for vaccine development.…”

Section: Future Preventive Toolsmentioning

confidence: 99%

“…2,6,11,12 The IgE initial sensitization is caused by hard-bodied tick bites from different species according to geographic location and is attributed to α-Gal-containing tick salivary glycoproteins, but also other tick salivary biomolecules without α-Gal modifications such as prostaglandin E2 (PGE2). [13][14][15][16][17] The mechanisms behind tick α-Gal induction of sensitization are still unknown, but besides the α-Gal moiety, tick sialome components may play an important role in the chained immune reaction activation (Figure 1). 18,19 Tick species such as Ixodes ricinus in Europe, Amblyomma americanum in North America, Haemaphysalis longicornis in Asia and Ixodes holocyclus in Australia are linked to AGS, 20 currently considered an emergent life-threatening allergy in tick endemic areas worldwide.…”

Section: Introductionmentioning

confidence: 99%

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Current and Future Strategies for the Diagnosis and Treatment of the Alpha-Gal Syndrome (AGS)

Vaz-Rodrigues¹,

Mazuecos²,

Fuente³

2022

JAA

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The α-Gal syndrome (AGS) is a pathognomonic immunoglobulin E (IgE)-mediated delayed anaphylaxis in foods containing the oligosaccharide galactose-α-1,3-galactose (α-Gal) such as mammalian meat or dairy products. Clinical presentation of AGS can also comprise immediate hypersensitivity due to anticancer therapy, gelatin-containing vaccines or mammalian serum-based antivenom. The IgE initial sensitization is caused by hard-bodied tick bites and symptomatic individuals typically develop delayed pruritus, urticaria, angioedema, anaphylaxis, malaise or gut-related symptoms. Due to inapparent presentation, delayed reactions and a wide variety of patients´ clinical history, the AGS diagnosis and treatment remain challenging. This review covers not only current diagnostic methods used for AGS such as the skin prick test (SPT), the oral food challenge (OFC), anti-α-Gal IgE levels measurement and the basophil activation test (BAT), but also potentially relevant next-generation diagnostic tools like the mast cell activation test (MAT), the histamine-release (HR) assay, omics technologies and model-based reasoning (MBR). Moreover, it focuses on the therapeutical medical and non-medical methods available and current research methods that are being applied in order to elucidate the molecular, physiological and immune mechanisms underlying this allergic disorder. Lastly, future treatment and preventive tools are also discussed, being of utmost importance for the identification of tick salivary molecules, with or without α-Gal modifications, that trigger IgE sensitivity as they could be the key for further vaccine development. Bearing in mind climate change, the tick-host paradigm will shift towards an increasing number of AGS cases in new regions worldwide, which will pose new challenges for clinicians in the future.

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“…5 TBD incidence has increased through the spread of ticks linked to climatic changes. Rodríguez et al, 25 made a conglomerate of global reports of diseases related to tick bites with a geographical distribution that included countries such as the US, UK, Russia, France, Argentina, Brazil, Spain, and Israel, among others. NCEZID, 26 in turn, reported on the increase of cases of Lyme disease that has occurred in the US from 2016 to 2017, from 26,203 to 29,513.…”

Section: Transmitted Diseasesmentioning

confidence: 99%

Background on the control of the cattle tick R. (B.) microplus and the use of coumarin substances as an alternative

Molano¹,

Torres²,

Monrroy³

2020

PPIJ

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Tick-borne diseases and autoimmunity: A comprehensive review

Cited by 15 publications

References 293 publications

In Vivo Characterization of Tick-Borne Encephalitis Virus in Bank Voles (Myodes glareolus)

In Vivo Characterization of Tick-Borne Encephalitis Virus in Bank Voles (Myodes glareolus)

Current and Future Strategies for the Diagnosis and Treatment of the Alpha-Gal Syndrome (AGS)

Background on the control of the cattle tick R. (B.) microplus and the use of coumarin substances as an alternative

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