Tick-Borne Bacteria and Host Skin Interface

Bernard, Quentin; Helezen, Ema; Boulanger, Nathalie

doi:10.1016/b978-0-12-811436-0.00009-5

Cited by 2 publications

(1 citation statement)

References 154 publications

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“…is not only transmitted by various soft tick species [156,[199][200][201][202] but also by hard ticks (Ixodes spp. [152,203]), which were previously considered non-vector-competent for TBRF Borrelia, serve as good example. The demand for an adequate ecological niche serving not only a specific animal host but also the transmitting tick species may be the main reason why TBRF is restricted to certain geographic areas.…”

Section: Plos Neglected Tropical Diseasesmentioning

confidence: 99%

Tick borne relapsing fever - a systematic review and analysis of the literature

et al. 2022

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Tick borne relapsing fever (TBRF) is a zoonosis caused by various Borrelia species transmitted to humans by both soft-bodied and (more recently recognized) hard-bodied ticks. In recent years, molecular diagnostic techniques have allowed to extend our knowledge on the global epidemiological picture of this neglected disease. Nevertheless, due to the patchy occurrence of the disease and the lack of large clinical studies, the knowledge on several clinical aspects of the disease remains limited. In order to shed light on some of these aspects, we have systematically reviewed the literature on TBRF and summarized the existing data on epidemiology and clinical aspects of the disease. Publications were identified by using a predefined search strategy on electronic databases and a subsequent review of the reference lists of the obtained publications. All publications reporting patients with a confirmed diagnosis of TBRF published in English, French, Italian, German, and Hungarian were included. Maps showing the epidemiogeographic mosaic of the different TBRF Borrelia species were compiled and data on clinical aspects of TBRF were analysed. The epidemiogeographic mosaic of TBRF is complex and still continues to evolve. Ticks harbouring TBRF Borrelia have been reported worldwide, with the exception of Antarctica and Australia. Although only molecular diagnostic methods allow for species identification, microscopy remains the diagnostic gold standard in most clinical settings. The most suggestive symptom in TBRF is the eponymous relapsing fever (present in 100% of the cases). Thrombocytopenia is the most suggestive laboratory finding in TBRF. Neurological complications are frequent in TBRF. Treatment is with beta-lactams, tetracyclines or macrolids. The risk of Jarisch-Herxheimer reaction (JHR) appears to be lower in TBRF (19.3%) compared to louse-borne relapsing fever (LBRF) (55.8%). The overall case fatality rate of TBRF (6.5%) and LBRF (4–10.2%) appears to not differ. Unlike LBRF, where perinatal fatalities are primarily attributable to abortion, TBRF-related perinatal fatalities appear to primarily affect newborns.

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Section: Plos Neglected Tropical Diseasesmentioning

confidence: 99%

Tick borne relapsing fever - a systematic review and analysis of the literature

et al. 2022

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Rôle immunomodulateur de la salive de tique dans la transmission d’agents infectieux

Boulanger

2018

Biologie Aujourd'hui

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Les tiques sont les vecteurs les plus importants de pathologies en médecine humaine et vétérinaire. Acariens strictement hématophages, ils produisent une salive riche en molécules bioactives qui ciblent la pharmacologie et l’immunité de l’hôte. Ce processus est absolument vital pour elles, car les tiques dures prennent des repas sanguins de plusieurs jours et doivent éviter leur rejet par l’hôte. Tous les acteurs de l’immunité sont ciblés par cette salive : l’immunité innée en lien avec les cellules résidentes de la peau et les cellules immunitaires et l’immunité adaptative liée aux lymphocytes T et B. La peau constitue donc un site particulier dans les maladies à transmission vectorielle. Au cours de leur longue co-évolution avec les tiques, les agents infectieux prennent avantage de cet environnement favorable pour être transmis efficacement dans la peau et se multiplier, pour ensuite se développer chez les hôtes vertébrés. La salive constitue pour ces microorganismes un véritable facteur de virulence qui augmente fortement leur pathogénicité.

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Tick-Borne Bacteria and Host Skin Interface

Cited by 2 publications

References 154 publications

Tick borne relapsing fever - a systematic review and analysis of the literature

Tick borne relapsing fever - a systematic review and analysis of the literature

Rôle immunomodulateur de la salive de tique dans la transmission d’agents infectieux

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