Ti3C2Tx MXene and polyoxometalate nanohybrid embedded with polypyrrole: Ultra-sensitive platform for the detection of osteopontin

Zhou, Sijie; Gu, C.; Li, Zhenzhen; Yang, Longyu; He, Linghao; Wang, Minghua; Huang, Xiaoyu; Zhou, Nan

doi:10.1016/j.apsusc.2019.143889

Cited by 92 publications

(53 citation statements)

References 67 publications

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“…The fabrication procedure of the developed aptasensor is represented in Figure 8 . The PPy@Ti 3 C 2 /PMo 12 -based aptasensor exhibited high selectivity and stability along with an extremely low detection limit of 0.98 fg mL −1 , and applicability in human serum samples [ 63 ].…”

Section: Classes Of Bioanalytical Sensors Based On Mxenesmentioning

confidence: 99%

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MXenes-Based Bioanalytical Sensors: Design, Characterization, and Applications

Khan

Andreescu

2020

Sensors

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MXenes are recently developed 2D layered nanomaterials that provide unique capabilities for bioanalytical applications. These include high metallic conductivity, large surface area, hydrophilicity, high ion transport properties, low diffusion barrier, biocompatibility, and ease of surface functionalization. MXenes are composed of transition metal carbides, nitrides, or carbonitrides and have a general formula Mn+1Xn, where M is an early transition metal while X is carbon and/or nitrogen. Due to their unique features, MXenes have attracted significant attention in fields such as clean energy production, electronics, fuel cells, supercapacitors, and catalysis. Their composition and layered structure make MXenes attractive for biosensing applications. The high conductivity allows these materials to be used in the design of electrochemical biosensors and the multilayered configuration makes them an efficient immobilization matrix for the retention of activity of the immobilized biomolecules. These properties are applicable to many biosensing systems and applications. This review describes the progress made on the use and application of MXenes in the development of electrochemical and optical biosensors and highlights future needs and opportunities in this field. In particular, opportunities for developing wearable sensors and systems with integrated biomolecule recognition are highlighted.

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Section: Classes Of Bioanalytical Sensors Based On Mxenesmentioning

confidence: 99%

“… Summary of different classes of biosensing platforms based on MXenes and their applications. Immunosensors (reprinted with permission from [ 62 ]) Aptasensors (reprinted with permission from [ 63 ]), Enzyme sensors (reprinted with permission from [ 64 ]). …”

Section: Figurementioning

confidence: 99%

MXenes-Based Bioanalytical Sensors: Design, Characterization, and Applications

Khan

Andreescu

2020

Sensors

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“…In this context, some POMs with oxidase or peroxidase‐like activity have been studied as colourimetric signal transducers, a type of optical transducers, for the detection of folate receptor . In addition, POMs have recently been explored as part of an electrochemical transducer system for the detection of osteopontin . These examples are summarized in Table and briefly described in the next paragraphs.…”

Section: Polyoxometalate Composites As Biosensorsmentioning

confidence: 99%

“…Using a completely different approach, Zhou and co‐workers developed a biosensor for the detection of osteopontin (OPN). OPN is a phosphoprotein that is overexpressed in multiple cancer types, regulates tumour metastasis, and conducts to cancer progression, and therefore has been explored as target analyte for early detection of cancer .…”

Section: Polyoxometalate Composites As Biosensorsmentioning

confidence: 99%

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Polyoxometalate Composites in Cancer Therapy and Diagnostics

et al. 2020

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Polyoxometalates (POMs) are metal‐oxide inorganic clusters, mostly anionic, where the metal is usually a transition metal (such as V, W, or Mo). Owing to their great variety of structures and large range of molecular dimensions, POMs have attracted considerable attention over the years. The high solubility in water together with the extent of their redox chemistry make POMs and their composites very versatile materials that find many applications in the biomedical field such as drug delivery systems or anti‐viral and anti‐tumoural agents. While the antitumoural activity of POMs and their derivatives is well documented, their application in emergent cancer therapies has not been addressed. This review presents the application of POM‐based composites as photothermal agents, radiosensitisers, and biosensors. The latest advances in the design of novel POM nanocomposites for cancer theranostics are also highlighted.

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