Ti3C2 MXene nanosheet-based capacitance immunoassay with tyramine-enzyme repeats to detect prostate-specific antigen on interdigitated micro-comb electrode

Chen, Jialun; Tong, Ping; Huang, Lingting; Yu, Zhonghua; Tang, Dianping

doi:10.1016/j.electacta.2019.07.010

Cited by 81 publications

(45 citation statements)

References 45 publications

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“…[98] To date, they have been functionalized with antibodies, DNA, enzymes, and aptamers, to impart features such as enhanced sensitivity or selectivity. [99][100][101][102][103] As Mxenes possess a large surface area, there is potential for immobilization of large amounts of biological molecules.…”

Section: Max Phasesmentioning

confidence: 99%

Additive Manufacturable Materials for Electrochemical Biosensor Electrodes

Elbadawi

Ong

Pollard

et al. 2020

Adv Funct Materials

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With the impending Industrial Revolution 4.0, the information produced by sensors will be central in many applications. This includes the healthcare sector, where affordable healthcare and precision medicine are highly sought after. Electrochemical sensors have the potential to produce affordable, high sensitivity and specificity, intuitive, and rapid point‐of‐care diagnostics. Underpinning these achievements is the choice of material and the fabrication thereof. In this review, the different types of materials used in electrochemical biosensors are reported, with a focus on synthetic conductive materials. The review demonstrates that there is an abundance of materials to select from, and compositing different types of materials further widens their applicability in biosensors. In addition, the fabrication of such materials using the state‐of‐the‐art of fabrication technology, additive manufacturing (AM), is also detailed. The need for compositing is evident in AM, as the feedstock for certain AM technologies is inherently nonconductive. Both material choice and fabrication technologies limitations are also discussed to highlight opportunities for growth. The review highlights how recent technological advancements have the potential to drive the healthcare industry toward achieving its primary goals.

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Section: Max Phasesmentioning

confidence: 99%

Additive Manufacturable Materials for Electrochemical Biosensor Electrodes

Elbadawi

Ong

Pollard

et al. 2020

Adv Funct Materials

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“…The characteristics of the developed system are shown in Figure 7 . Despite these merits, one of the limitations of this immunosensor is the complex fabrication procedure and long reaction time as compared to commercial enzyme-linked immunosorbent assays [ 86 ].…”

Section: Classes Of Bioanalytical Sensors Based On Mxenesmentioning

confidence: 99%

“… Analytical performance of the developed immunoassay ( A ) capacitance responses of Ti 3 C 2 MXene-based interdigitated immunosensor toward target PSA standards; ( B ) the corresponding calibration plots; and ( C ) the specificity of capacitance immunosensor against target PSA and non-targets including AFP, CEA, and CA 125 (reproduced with permission from reference [ 86 ]). …”

Section: Figurementioning

confidence: 99%

MXenes-Based Bioanalytical Sensors: Design, Characterization, and Applications

Khan

Andreescu

2020

Sensors

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MXenes are recently developed 2D layered nanomaterials that provide unique capabilities for bioanalytical applications. These include high metallic conductivity, large surface area, hydrophilicity, high ion transport properties, low diffusion barrier, biocompatibility, and ease of surface functionalization. MXenes are composed of transition metal carbides, nitrides, or carbonitrides and have a general formula Mn+1Xn, where M is an early transition metal while X is carbon and/or nitrogen. Due to their unique features, MXenes have attracted significant attention in fields such as clean energy production, electronics, fuel cells, supercapacitors, and catalysis. Their composition and layered structure make MXenes attractive for biosensing applications. The high conductivity allows these materials to be used in the design of electrochemical biosensors and the multilayered configuration makes them an efficient immobilization matrix for the retention of activity of the immobilized biomolecules. These properties are applicable to many biosensing systems and applications. This review describes the progress made on the use and application of MXenes in the development of electrochemical and optical biosensors and highlights future needs and opportunities in this field. In particular, opportunities for developing wearable sensors and systems with integrated biomolecule recognition are highlighted.

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“…Moreover, the prepared biosensor showed the negligible decrease of the response current values over 300 scanning cycles, which was remarkably stable in comparison to the other control biosensors prepared with only MXene or only graphene. Moreover, numerous other major studies on MXene-based enzymatic electrochemical biosensors are currently underway [ 20 ].…”

Section: Mxene-based Electrochemical Biosensorsmentioning

confidence: 99%

“…MXenes are two-dimensional inorganic compounds with a thickness of a few atomic layers and are composed of transition metal carbides, nitrides, or carbonitrides such as titanium carbide (Ti 3 C 2 ) and titanium carbonitride (Ti 2 CN), which confers them with exceptional characteristics, including high conductivity and superior fluorescent, optical, and plasmonic properties. [ 20 , 21 , 22 ]. Just as graphene and carbon nanotubes (CNTs) received great attention as new nanomaterials in the past, MXenes have been receiving much attention recently.…”

Section: Introductionmentioning

confidence: 99%

Recent Advances in MXene Nanocomposite-Based Biosensors

et al. 2020

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The development of advanced biosensors with high sensitivity and selectivity is one of the most demanded concerns in the field of biosensors. To meet this requirement, up until now, numerous nanomaterials have been introduced to develop biosensors for achieving high sensitivity and selectivity. Among the latest nanomaterials attracting attention, MXene is one of the best materials for the development of biosensors because of its various superior properties. MXenes are two-dimensional inorganic compounds with few atomic layers that possess excellent characteristics including high conductivity and superior fluorescent, optical, and plasmonic properties. In this review, advanced biosensors developed on the basis of the MXene nanocomposite are discussed with the selective overview of recently reported studies. For this, introduction of the MXene including the definition, synthesis methods, and its properties are discussed. Next, MXene-based electrochemical biosensors and MXene-based fluorescent/optical biosensors are provided, which are developed on the basis of the exceptional properties of the MXene nanocomposite. This review will suggest the direction for use of the Mxene nanocomposite to develop advanced biosensors with high sensitivity and selectivity.

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Ti3C2 MXene nanosheet-based capacitance immunoassay with tyramine-enzyme repeats to detect prostate-specific antigen on interdigitated micro-comb electrode

Cited by 81 publications

References 45 publications

Additive Manufacturable Materials for Electrochemical Biosensor Electrodes

Additive Manufacturable Materials for Electrochemical Biosensor Electrodes

MXenes-Based Bioanalytical Sensors: Design, Characterization, and Applications

Recent Advances in MXene Nanocomposite-Based Biosensors

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