Ti₃C₂ nanosheets with broad-spectrum antioxidant activity for cytoprotection against oxidative stress

Abstract

Ti3C2 nanosheets exhibit efficient and broad-spectrum antioxidant activities to scavenge ROS and free radicals, playing a significant role in preventing cell damage against oxidative stress.

A Ti3C2 MXene-integrated near-infrared-responsive multifunctional porous scaffold for infected bone defect repair

“…For Ti 3 C 2 MXenes, Ti species with an unsaturated valence state and their quasi-metallic property induced superior electron transfer ability, endowing Ti 3 C 2 MXenes with efficient and broadspectrum antioxidant capability. 30 As mentioned previously, trauma and infection could lead to an increase in ROS generation. 63 Furthermore, an important side effect of PTT is inflammation because the adjacent hyperthermia-induced necrotic cells release excessive ROS.…”

MXene-based nanomaterials with enzyme-like properties for biomedical applications

“…MXene-based nanozymes have important applications in antioxidants, which can scavenge excessive intracellular ROS to realize powerful cytoprotective effects. [85][86][87][88][89][90][91] For example, the 2D vanadium carbide V 2 C nanozyme was constructed to alleviate ROS-mediated inflammatory and neurodegenerative diseases (Fig. 9).…”

“…Following a similar mechanism described above, several MXene-based nanomaterials displayed SOD and CAT-like activities. 86–91 Ren et al 91 prepared the polyvinylpyrrolidone (PVP)-modified Nb 2 C nanosheets by liquid-phase exfoliation. They discovered that the obtained Nb 2 C had SOD-like properties.…”

Radiotherapy Enhancement by Ti3C2Tx MXenes

“…Interestingly, equi-dosed aged MXenes were tolerated by cells even better, showing no effect on cell viability up to 40 µg/ml at the 24h time point. The higher effects of fresh MXenes on cell viability can likely be attributed to the following factors: i) a change in oxygen availability in the cell environment 22,38 through (slow) oxidation of as-synthesized MXenes (in contrast to the more stable aged MXenes); ii) the sharp edges of MXenes inducing membrane damage; 28,39 or iii) further more complex (biological) mechanisms. However, oxidative stress caused by MXene exposure has been subject to controversy 28,38,39 and is likely dependent on the cellular environment and exposure times.…”