Ti Breast Cancer Associated with Von Recklinghausen’s Neurofibromatosis

Abstract

A rare case of breast cancer associated with von Recklinghausen s neurofibromatosis is reported. This case and review of the literature illustrate the problems of clinical diagnosis. A 66-year-old woman who had undergone sigmoidectomy for sigmoid colon cancer two years previously, was admitted to the hospital because of a left breast skinretraction in October, 1998. The patient had von Recklinghausen fs disease (neurofibromatosis type 1). The TNM clinical staging was T1cN0M0. Modified radical mastectomy was performed. The histopathological diagnosis of the breast tumor was invasive ductal carcinoma and the skin tumor was neurofibroma. The pTNM pathological staging was pT1cN1aM0. Among patients similar to our case, almost all were staged higher than T2. This may be because multiple neurofibromas obscure breast mass at palpation, leading to delayed detection of the cancer. Systemic and careful exploration is essential for patients with von Recklinghausen's neurofibromatosis to detect breast cancer at an early stage.

Neoplasms Associated with Germline and Somatic NF1 Gene Mutations

“…There is a paucity of information on this topic in the English language; Murayama et al have reported on 34 NF1 patients with 38 breast cancers [199]. Sørensen et al reported 57 non-neurologic malignancies in a cohort of 212 patients with NF1 [25].…”

Male breast cancer with neurofibromatosis- a rare presentation

“…Murayama et al reported 37 cases of breast cancer associated with NF1; most OF cases were diagnosed at an advanced stage and had invasive ductal carcinoma. 13 In an earlier report by Nakamura et al, the authors noted that breast cancer5 affected young woman (<35 years old), in 18.5% of the cases which is relatively high when compared. 9 To the findings of other series of breast cancer not associated with NF 1, which reported a percentage of 6.7%.…”

Breast cancer associated with type 1 neurofibromatosis

“…The association of NF1 with breast cancer is rare in the literature [6][7][8][9][10][11][12][13]. Additionally, two cases of Paget's disease of the breast [14,15] and a case of anaplastic breast carcinoma [16] have been reported in patients with NF1.…”