THz spectroscopy to probe long-range electrodynamic interactions between proteins

Ruffenach, Sandra; Lechelon, Mathias; Meriguet, Yoann; Gori, Matteo; Nardecchia, I.; Floriani, Elena; Coquillat, Dominique; Теппе, Ф.; Mailfert, Sébastien; Marguet, Didier; Ferrier, Pierre; Varani, L.; Sturgis, James N.; Pettini, Marco; Torres, J.

doi:10.1109/irmmw-thz50927.2022.9896089

Cited by 1 publication

(1 citation statement)

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“…For example, synchronized transition dipole oscillations from a vibrational exciton comprising n molecular units would achieve a n enhancement of the transition dipole magnitude. It has been previously proposed , that out-of-thermal-equilibrium collective oscillations of biomolecules leading to the formation of Fröhlich condensates can result in the formation of such giant vTDMs, of the order of 10 3 D . This would increase the interaction energy between the molecules well beyond the level of thermal noise.…”

Section: Results and Discussionmentioning

confidence: 98%

Vibrational Dipole–Dipole Coupling and Long-Range Forces between Macromolecules

Sasihithlu,

Scholes

2024

J. Phys. Chem. B

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Long-range interactions between biomacromolecules are considered important for directing intracellular processes. Recent studies have posited that interactions between oscillating dipoles are well-suited to mediating long-range forces because they are weakly screened by a dielectric environment. Here, we extend these studies and present a quantum electrodynamic mechanism for resonant interactions between vibrational transition dipole moments of molecules. We explicitly consider the molecular charge density oscillations as IR transition dipoles. This gives a physical, molecular assignment to the idea of oscillating dipoles and allows us to develop explicit expressions for the interactions that can be quantified using parameters known from experiment. Moreover, in the same framework, we can describe van der Waals forces. We use numerical calculations to estimate the strength of resonant vibrational dipole− dipole interactions over long distances and compare these estimates to the van der Waals interaction. We find that the resonant vibrational dipole−dipole interactions dominate over the long range.

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