THz spectroscopy and imaging for breast cancer detection in the 300–500 GHz range

Al-Ibadi, Amel; Cassar, Quentin; Zimmer, Thomas; MacGrogan, Gaëtan; Mavarani, Laven; Hillger, Philipp; Grzyb, Janusz; Pfeiffer, Ullrich R.; Guillet, Jean-Paul; Mounaix, Patrick

doi:10.1109/irmmw-thz.2017.8067037

Cited by 6 publications

(3 citation statements)

References 4 publications

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“…Moreover, groups in France and Germany also successfully performed breast cancer imaging in the 300 -500 GHz frequency range. The chosen frequency is in this range [25]. The actual breast cancer tumors' actual size varies from less than 1 cm to sizes more than 5 cm [26].…”

Section: Methodsmentioning

confidence: 99%

Design of THz High-Resistivity Silicon-Based Microstrip Antenna for Breast Cancer Imaging

Andhyka¹,

Apriono²

2020

Int. J. Adv. Sci. Eng. Inf. Technol.

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Cancer is the second deadliest disease globally, with approximately 18 million cases and 9.6 million deaths in 2018. There were 2.088 million breast cancer cases and 627 thousand deaths. This cancer is the second most prevalent after lung cancer, resulting in the fifth most cancer deaths worldwide. A critically important technique for the detection of primary-stage tumors or cancer is imaging. Early detection of cancer is necessary to minimize the number of fatalities associated with breast cancer. Several techniques have been applied to breast tissue imaging such as computed tomography scans (CT Scans), transrectal ultrasound (TRUS), magnetic resonance imaging (MRI), positron emission tomography (PET), and single-photon emission computed tomography (SPECT), but these techniques have well-known limitations. THz imaging is also one of the techniques for early detection. THz imaging approaches address key deficiencies in alternative techniques and are typically non-ionizing, non-contact, non-destructive, and have a high spatial resolution. An appropriate detector is a crucial aspect of the development of this promising technique. In this report, a THz siliconbased antenna with a frequency centered at 0.312 THz is proposed for application to breast cancer imaging. A silicon substrate has a high permittivity and is useful for device miniaturization. Inset-fed and array techniques are essential for focusing the beamwidth in the desired direction. The results show that the proposed design can be used to develop a directional antenna with reliable performance. This study will contribute to the development of a THz imaging system for early breast cancer detection.

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Section: Methodsmentioning

confidence: 99%

Design of THz High-Resistivity Silicon-Based Microstrip Antenna for Breast Cancer Imaging

Andhyka¹,

Apriono²

2020

Int. J. Adv. Sci. Eng. Inf. Technol.

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“…The conventional medical imaging techniques uses X-rays, Magnetic resonance imaging, Ultrasound, Computer tomography and positron emission which are of low resolution and high cost for implementation and complex systems in which X-rays used in mammography for detection of detection of breast tumor where a high false negative rate of (4-34%) and high false positive rate of (70%) have reported [13]. The potential of (0.3-0.5 THz) frequencies in the cancer detection near field imager discussed in [14]. THz reflection imaging to distinguish between cancer and non-cancer breast tissue discussed in [15].…”

Section: Introductionmentioning

confidence: 99%

Metamaterial inspired THz antenna for breast cancer detection

Geetharamani

Aathmanesan

2019

SN Appl. Sci.

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Metamaterial inspired Terahertz (THz) antenna for breast cancer detection proposed in this paper. The proposed antenna consists of a simple rectangular patch configuration integrated with Complementary Split Ring Resonator (CSRR). The design equations along with the equivalent circuit and permittivity calculations also presented in this paper. The experimental technique for detection of tumor in human breast model by the simulation technique also presented. The proposed metamaterial inspired antenna operates at 1 THz frequency with 20 dBi of gain. Its design evolution process, parametric study, and results such as farfield radiations also presented in this paper.

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“…It has been suggested that the substantial contrast between normal and abnormal tissues arises from the different water content to which THz-photons are sensitive [28]. Worldwide, the accumulation of data is expanding to certify the ability of the THz range to provide tissue recognition based on dielectric properties [29,30]. Moreover, image processing techniques are studied and developed to improve the visualization of THz-images [31].…”

Section: Introductionmentioning

confidence: 99%

Pilot study of freshly excised breast tissue response in the 300 – 600 GHz range

Cassar¹,

Al-Ibadi²,

Mavarani³

et al. 2018

Biomed. Opt. Express

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The failure to accurately define tumor margins during breast conserving surgery (BCS) results in a 20% re-excision rate. The present paper reports the investigation to evaluate the potential of terahertz imaging for breast tissue recognition within the under-explored 300 - 600 GHz range. Such a frequency window matches new BiCMOS technology capabilities and thus opens up the opportunity for near-field terahertz imaging using these devices. To assess the efficacy of this frequency band, data from 16 freshly excised breast tissue samples were collected and analyzed directly after excision. Complex refractive indices have been extracted over the as-mentioned frequency band, and amplitude frequency images show some contrast between tissue types. Principal component analysis (PCA) has also been applied to the data in an attempt to automate tissue classification. Our observations suggest that the dielectric response could potentially provide contrast for breast tissue recognition within the 300 - 600 GHz range. These results open the way for silicon-based terahertz subwavelength near field imager design, efficient up to 600 GHz to address ex vivo life-science applications.

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THz spectroscopy and imaging for breast cancer detection in the 300–500 GHz range

Cited by 6 publications

References 4 publications

Design of THz High-Resistivity Silicon-Based Microstrip Antenna for Breast Cancer Imaging

Design of THz High-Resistivity Silicon-Based Microstrip Antenna for Breast Cancer Imaging

Metamaterial inspired THz antenna for breast cancer detection

Pilot study of freshly excised breast tissue response in the 300 – 600 GHz range

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