Thyroxine-Binding Proteins

Biophysical Optimization of a Therapeutic Protein by Nonstandard Mutagenesis

“…Critical to the growth, development, and metabolic homeostasis of vertebrates (including humans) (79), thyroid hormone and its various protein complexes have been extensively studied (80). Co-crystal structures of thyroid hormone-protein complexes (employing transthyretin, thyroid hormone receptor, and thyroxine-binding globulin) and related model complexes have revealed hormone binding pockets that enclose the iodine atoms within nonpolar cavities or crevices (70 -72).…”

Developmental neurotoxicity of polybrominated diphenyl ether (PBDE) flame retardants

“…Whether the hypothesized mechanisms of PBDEinduced hypothyroxemia (induction of UDPGT and interference with TTR) are operational in humans remains to be determined. For example, as the major T 4 transporter in humans is believed to be a thyroid-binding globulin (TBG), followed by TTR and albumin (Schussler, 2000;Palha, 2002), the impact of PBDE binding to TTR may be lower in humans than in rodents. Furthermore, hydroxylated PCBs bind to TBG with much lower affinity than to TTR (Lans et al 1994), and the same may be true for hydrolated PBDEs.…”

Ten-Year Follow-up of Children Born at <30 Weeks’ Gestational Age Supplemented With Thyroxine in the Neonatal Period in a Randomized, Controlled Trial

“…At present, there is more knowledge on FT4 concentrations, which are more important for the biological effect than bound-T4 concentrations. 21 FT4 concentrations are decreased to a much lesser extent than bound-T4 concentrations, [3][4][5] and thyroid-hormone deficiency in preterm infants seems to be a subtle problem that increases in severity in more immature infants. 5,22 In view of the results discussed above, our present results can be of importance for additional studies.…”