Thyrotropin-releasing hormone axonal varicosities appear to innervate dopaminergic neurons in the human hypothalamus

Dudás, Bertalan; Merchenthaler, Istvån

doi:10.1007/s00429-020-02120-8

Cited by 5 publications

(2 citation statements)

References 56 publications

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“…Another association between PRL and NDs is TRH, which is a well-known regulator of PRL secretion in tuberoinfundibular dopamine neurons [70,71]. Like other hormones, such as PRL, TRH administration has been studied in neuroprotection [72].…”

Section: Evidence Of the Role Of Prolactin In Alzheimer's Diseasementioning

confidence: 99%

Neuroprotection Mediated by Prolactin during Excitotoxicity: New Functions and Insights

Molina-Salinas,

Rodríguez-Chávez,

Cerbón

2024

Drug Development and Safety

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Prolactin (PRL) is a peptide and pleiotropic hormone with more than 300 associated functions such as maternal behavior, lactation, osmoregulation, angiogenesis, and the immune system. It is associated with several functions in the brain, including lactation, cognition and memory, maternal behavior, and neurogenesis. PRL reportedly plays an important role in neuroprotection against excitotoxicity caused by glutamate (Glu) and kainic acid (KA) damage in vitro and in vivo models. However, the molecular mechanisms involved in the neuroprotective effects of PRL are unclear. Despite this, data suggest the involvement of PI3K/AKT, and GSK3β/NF-κB signaling pathways, which are involved in neuroprotection. In addition, PRL inhibits Glu- and KA-induced increase by intracellular Ca2+ concentration, leading to neuronal survival. We also discuss current knowledge on the role of PRL in neurodegenerative diseases. New avenues of research into the protective mechanisms of PRL and its potential therapeutic effects on the brain under pathological and physiological conditions are needed.

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Section: Evidence Of the Role Of Prolactin In Alzheimer's Diseasementioning

confidence: 99%

Neuroprotection Mediated by Prolactin during Excitotoxicity: New Functions and Insights

Molina-Salinas,

Rodríguez-Chávez,

Cerbón

2024

Drug Development and Safety

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“…In another study, which utilized the technique of in situ hybridization histochemistry, researchers identified a specific subtype of TRH-R1 mRNA that was predominantly expressed in hypothalamic regions, including the arcuate nucleus [ 59 ]. Additionally, TRH neurons make synaptic contact with TIDA neurons [ 60 ]. TRH binding sites are found in TIDA neurons, and TRH potently and robustly increases DA release and intracellular calcium concentrations in these cells [ 61 ].…”

Section: Tida Neuronsmentioning

confidence: 99%

Current Review of the Function and Regulation of Tuberoinfundibular Dopamine Neurons

Qi-Lytle,

Sayers,

Wagner

2023

IJMS

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Tuberoinfundibular dopamine (TIDA) neurons have cell bodies located in the arcuate nucleus of the mediobasal hypothalamus. They project to the external zone of the median eminence, and the dopamine (DA) released there is carried by the hypophysial portal vasculature to the anterior pituitary. The DA then activates D2 receptors to inhibit prolactin (PRL) secretion from lactotrophs. The TIDA neuronal population is the principal regulatory factor controlling PRL secretion. The neuroendocrine role subserved by TIDA neurons sets them apart from other dopaminergic populations like the nigrostriatal and mesolimbic DA neurons. TIDA neurons exhibit intrinsic oscillatory fluctuations in their membrane potential that give rise to phasic firing and bursting activity. TIDA neuronal activity is sexually differentiated and modulated by gonadal hormones and PRL, as well as an array of small molecule and peptide neurotransmitters. This review covers these characteristics.

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Multifactorial Regulation of the Activity of Hypophysiotropic Thyrotropin-Releasing Hormone Neurons

Joseph‐Bravo

Jaimes-Hoy

Rodríguez-Rodríguez

et al. 2021

Masterclass in Neuroendocrinology

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Thyrotropin-releasing hormone axonal varicosities appear to innervate dopaminergic neurons in the human hypothalamus

Cited by 5 publications

References 56 publications

Neuroprotection Mediated by Prolactin during Excitotoxicity: New Functions and Insights

Neuroprotection Mediated by Prolactin during Excitotoxicity: New Functions and Insights

Current Review of the Function and Regulation of Tuberoinfundibular Dopamine Neurons

Multifactorial Regulation of the Activity of Hypophysiotropic Thyrotropin-Releasing Hormone Neurons

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