Thyrotoxicosis Involves β2-Adrenoceptor Signaling to Negatively Affect Microarchitecture and Biomechanical Properties of the Femur

Neofiti-Papi, Bianca; Albuquerque, Rudá Prestes e; Miranda-Rodrigues, Manuela; Gonçalves, Nathalia; Jorgetti, Vanda; Brum, Patrícia C.; Ferreira, Julio Cesar Batista; Gouveia, Cecília Helena de Azevedo

doi:10.1089/thy.2018.0259

Cited by 6 publications

(4 citation statements)

References 49 publications

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“…Osteocalcin has been proposed as a biomarker for OA detection and monitoring. Its biologic function is considered to be related to the inhibition of bone matrix mineralization [35,36]. In addition, multiple cross-sectional studies have found that FT3/FT4, TSHI, and TT4RI are significantly correlated with chronic kidney disease (CKD), non-alcoholic fatty liver disease (NAFLD), and coronary artery disease (CAD) [37][38][39].…”

Section: Discussionmentioning

confidence: 99%

Association between sensitivity to thyroid hormone indices and the risk of osteoarthritis: an NHANES study

et al. 2022

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Objectives Thyroid hormones play an instrumental role in chondrogenic differentiation and matrix maturation. However, studies investigating the relationship between thyroid function and the risk of osteoarthritis (OA) remain scarce. This study was designed to investigate the correlation between thyroid status and OA from a novel perspective of sensitivity to thyroid hormones. Methods The study included 8478 people from the National Health and Nutrition Examination Survey (NHANES) 2007–2010. The sensitivity to thyroid hormone indices included Thyrotroph Thyroxine Resistance Index (TT4RI), Thyroid-stimulating hormone (TSHI), Thyroid Feedback Quantile-based Index (TFQI), and Free Triiodothyronine /Free thyroxine (FT3/FT4), which were calculated based on serum free triiodothyronine (FT3), free thyroxine (FT4), and thyroid stimulating hormone (TSH). Considering the complex survey design and sample weights, we employed multivariate linear regression models and stratified analysis to evaluate the correlation between sensitivity to thyroid hormone indices and OA. Results Study results indicated that participants with OA had elevated TT4RI, TSHI, and TFQI levels, and lower FT3/FT4 levels compared to those with non-arthritis. After adjusting for other covariates, FT3/FT4 was negatively associated with the risk of OA (OR = 1.162, 95%CI 1.048–1.478, P = 0.021); (OR = 1.261, 95%CI 1.078–1.623, P = 0.042). In subgroup analyses stratified by gender and BMI, participants with OA had higher TFQI levels compared to those without OA in both genders. (OR = 1.491, 95%CI 1.070–2.077, P = 0.018); (OR = 2.548, 95%CI 1.929–3.365, P < 0.001). The higher TFQI levels were consistently associated with the increased prevalence of OA in the BMI (< 18.5 kg/m2) group after adjusting for different covariates, but not in other BMI groups. In, addition, TFQI performed better than FT3/FT4, TSHI, and TT4RI on ROC analyses for OA prediction. Conclusions The levels of FT3/FT4, TSHI, TT4RI, and TFQI are strongly associated with the prevalence of OA, which illustrates the complex correlation between the thyroid system and chondrogenic differentiation. TFQI may be used as a helpful indicator to predict OA and provide novel ideas for the evaluation and treatment of OA.

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Section: Discussionmentioning

confidence: 99%

Association between sensitivity to thyroid hormone indices and the risk of osteoarthritis: an NHANES study

et al. 2022

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“…The impact on osteoblasts is demonstrated by stimulating the expression of osteocalcin and promoting bone formation, facilitating osteoblast differentiation, suppressing osteoblast proliferation, and contributing to the maintenance of bone mass. The effect on osteoclasts is evidenced by an increase in tartrate-resistant acid phosphatase (TRAP) expression and the promotion of osteoclastogenesis, facilitating the differentiation of osteoclasts and aiding in the preservation of bone density ( 103–105 ).…”

Section: Iodine and Kashin-beck Diseasementioning

confidence: 99%

Effects of selenium and iodine on Kashin-Beck disease: an updated review

Liu,

Luo,

Wen

et al. 2024

Front. Nutr.

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Kashin-Beck disease (KBD) is an endochondral osteogenesis disorder characterised by epiphysis damage and secondary deformable arthropathy induced by multiple external factors, among which selenium (Se) and iodine deficiency are important influencing factors. Iodine deficiency is usually accompanied by a low Se content in the soil in the KBD areas of China. Se can reverse oxidative damage to chondrocytes. In addition, Se is related to the bone conversion rate and bone mineral density. Low Se will hinder growth and change bone metabolism, resulting in a decrease in the bone conversion rate and bone mineral density. Thyroid hormone imbalance caused by thyroid dysfunction caused by iodine deficiency can damage bone homeostasis. Compared with Se deficiency alone, Se combined with iodine deficiency can reduce the activity of glutathione peroxidase more effectively, which increases the vulnerability of chondrocytes and other target cells to oxidative stress, resulting in chondrocyte death. Clinical studies have shown that supplementation with Se and iodine is helpful for the prevention and treatment of KBD.

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“…Osteoclasts are derived from hematopoietic progenitors and promote bone resorption ( 49 ). Studies showed that T3 increased the RANKL/OPG ratio in the femur in wild-type mice but not in β2-adrenergic receptor (AR) -/- mice, indicated that T3 activated osteoclasts function through the β2-AR pathway in bone ( 50 ). In addition, thyrotoxicosis impaired bone mineral density (BMD) in WT mice, and the stimulative effect to bone resorption was more stronger than bone formation ( 51 ), however, BMD was not significantly decreased in response to the supraphysiological dose of T3 in α2A/C-AR double knockout mice, suggesting that α2-AR mediated T3-induced bone resorption ( 52 ).…”

Section: Effects Of Ths On Bonementioning

confidence: 99%

Endocrine Regulation on Bone by Thyroid

Zhu

Pang

et al. 2022

Front. Endocrinol.

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BackgroundAs an endocrine organ, the thyroid acts on the entire body by secreting a series of hormones, and bone is one of the main target organs of the thyroid.SummaryThis review highlights the roles of thyroid hormones and thyroid diseases in bone homeostasis.ConclusionThyroid hormones play significant roles in the growth and development of bone, and imbalance of thyroid hormones can impair bone homeostasis.

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Thyrotoxicosis Involves β2-Adrenoceptor Signaling to Negatively Affect Microarchitecture and Biomechanical Properties of the Femur

Cited by 6 publications

References 49 publications

Association between sensitivity to thyroid hormone indices and the risk of osteoarthritis: an NHANES study

Association between sensitivity to thyroid hormone indices and the risk of osteoarthritis: an NHANES study

Effects of selenium and iodine on Kashin-Beck disease: an updated review

Endocrine Regulation on Bone by Thyroid

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