A retrospective 5 year study of thyrotoxicosis at Mulago Hospital, Uganda is presented. 30 cases were analysed and features pertaining to the clinical pattern are described. Comment is made on 5 cases which had associated cardiovascular abnormalities. The increased incidence of the condition in Uganda and other parts of Africa is noted. It is suggested that this may provide the opportunity for workers to follow up larger series, and assess the clinical, epidemiological and immunological aspects of the disease which could provide important clues as regards the genesis of thyrotoxicosis.