Thyrotoxic periodic paralysis: Two case studies

Darrow, Marc; Brammer, Werner K.; Rowley, Allan

doi:10.1016/s0003-9993(95)80641-5

Cited by 13 publications

(10 citation statements)

References 13 publications

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“…During previous episodes of weakness when the patients did not come to the hospital for treatment, the attacks commonly lasted from 3 to 48 hours, which is similar in duration to attacks reported by others. 11,22 There was no correlation in our study between recovery time and potassium chloride dose (r = 0.17). Rebound hyperkalemia occurred in 42% of our 24 episodes of hospitalized patients with TPP, with a maximum serum K level of 6.6 mmol/L, and this phenomenon is well described in the literature.…”

Section: Commentcontrasting

confidence: 53%

See 1 more Smart Citation

Clinical and Metabolic Features of Thyrotoxic Periodic Paralysis in 24 Episodes

Manoukian¹,

Foote²,

Crapo³

1999

Arch Intern Med

217

183

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Section: Commentcontrasting

confidence: 53%

“…In another study, 22 treatment with potassium chloride, 130 mEq orally or 20 mEq intravenously, in 100 cm 3 of normal saline was recommended based on experience with 2 patients. More than 40% of our patients had rebound hyperkalemia, 80% of whom received more than 90 mEq of potassium chloride within 24 hours.…”

Section: Commentmentioning

confidence: 99%

Clinical and Metabolic Features of Thyrotoxic Periodic Paralysis in 24 Episodes

Manoukian¹,

Foote²,

Crapo³

1999

Arch Intern Med

217

183

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“…A high carbohydrate meal, warm weather, increased physical exertion, insulin, adrenaline, and potassium sparing diuretics are usual precipitants. 4 Proximal muscles of the limbs (lower > upper) are affected with sparing of the sensory system, higher mental functions, and cranial nerves. Patients can present with respiratory failure, 5 cardiac arrhythmias, and thyrotoxic crisis.…”

Section: Discussionmentioning

confidence: 99%

Thyrotoxic periodic paralysis: an unusual presentation of weakness

Paul

2003

Emerg Med J

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Thyrotoxic periodic paralysis is a rare endocrine disorder seen predominantly in men of Asian origin. The case is reported of a patient who presented to the accident and emergency department with sudden onset of weakness of his lower limbs. Hypokalaemia was identified and treated with resolution of symptoms. Additional tests identified the patient as being thyrotoxic. He was treated with oral antithyroid drugs. It is important to consider the diagnosis of thyrotoxic periodic paralysis in patients presenting with acute onset of weakness. The report discusses the epidemiology, presentation, treatment, and complications of this condition.

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“…Apesar de não existirem estudos comparativos quanto ao método de tratamento, a conduta mais freqüente na literatura é o controle rápido da tireotoxicose com tiamazol ou propiltiouracil associado ao propranolol e seguido pela terapia com iodo radioativo. Após atingir o estado eutireoidiano clínico e laboratorial, um período de até seis meses pode ser necessário para o completo desaparecimento das crises de paralisia, que vão diminuindo em freqüência e intensidade (35). A grande maioria dos episódios de paralisia tireotóxica melhora espontaneamente em algumas horas sem qualquer tratamento específico.…”

Section: Discussionunclassified

Paralisia periódica hipocalêmica tireotóxica: relato de 3 casos

Dias¹,

Moura²,

Gomes³

et al. 2004

Arq Bras Endocrinol Metab

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Thyrotoxic hypokalemic periodic paralysis (THPP) is a rare hyperthyroidism complication much more frequent in Asians and Caucasians. We present 3 cases of THPP occurring in Brazilian male patients with 28 years old (y) (Case 1), 29 y (Case 2) and 60 y (Case 3), respectively. They were admitted following an episode of flacid paralysis of extremities. Whereas case 1 reported recurring episodes of paralysis crises, cases 2 and 3 reported only one episode. Signs and symptoms of thyrotoxicosis, such as weigh loss, diaphoresis, extremities tremor, palpitation and mild diffuse goiter were present in the first case; while the second case only presented ophthalmopathy and the third patient referred that 2 years before his admission he presented an episode of cardiac arrhythmia but did not have thyroid function evaluation at that time. Their laboratory findings were hypokalemia, low TSH and raised free T4. They were treated with intravenous potassium, oral propranolol and tiamazol with remission of the symptoms. We report these cases to emphasize the importance of recognizing hyperthyroid periodic paralyses to avoid missing a treatable and curable condition.

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Thyrotoxic periodic paralysis: Two case studies

Cited by 13 publications

References 13 publications

Clinical and Metabolic Features of Thyrotoxic Periodic Paralysis in 24 Episodes

Clinical and Metabolic Features of Thyrotoxic Periodic Paralysis in 24 Episodes

Thyrotoxic periodic paralysis: an unusual presentation of weakness

Paralisia periódica hipocalêmica tireotóxica: relato de 3 casos

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