Thyrotoxic Periodic Paralysis in a Patient Abusing Thyroxine for Weight Reduction

Chen, Yung‐Chang; Fang, Ji‐Tseng; Chang, Chin-Tung; Chou, Hsin-Hua

doi:10.1081/jdi-100001294

Cited by 36 publications

(28 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Hyperthyroidism is associated with weight loss through an increased metabolic rate. Exogenous thyroid hormone use has been associated with episodes of thyroid storm as well as thyrotoxic periodic paralysis [66,67]. Thyrotoxic periodic paralysis is an acute complication of thyrotoxicosis and often seen in those of Asian descent [68].…”

Section: Thyroid Hormonementioning

confidence: 99%

Toxicity of Weight Loss Agents

2012

View full text Add to dashboard Cite

Introduction: With the rise of the obesity epidemic in the United States over the last several decades and the medical complications seen with it, weight loss and dieting have become a national public health concern. Discussion: Because of their increased use and availability through internet sales, several different dieting agents were reviewed for potential toxicity. These included: syrup of ipecac, cathartics, human chorionic gonadotropin hormone, 2,4 Dinitrophenol, guar gum, phenylpropanolamine, ma huang/ ephedra, caffeine, clenbuterol, fenfluramine, sibutramine, thyroid hormone, orlistat and cannabinoid antagonists. Conclusions: With the internet making even banned products readily accessible, healthcare providers need to be aware of the potential toxicities of a wide range of weight loss agents. Our review covered topics we thought to be most historically significant as well as pertinent to the practice of medical toxicology today.

show abstract

Section: Thyroid Hormonementioning

confidence: 99%

Toxicity of Weight Loss Agents

2012

View full text Add to dashboard Cite

show abstract

“…As freqüências foram maiores entre as mulheres mais jovens e obesas e de nível sócio-econômico mais elevado (valor de p < 0,001). Os níveis de TSH foram estatisticamente menores entre as usuárias de fórmulas (1,96 mUI/ml; IC 95% = 1,93-1,98) comparados com usuárias prévias 2,83 mUI/ml (IC 95% = 2,13-3,02) e não usuárias 2,59 mUI/ml (IC 95% = 2,20-3,21 (1)(2)(3). A study in two Brazilian metropolitan cities have also shown that four to six active components predominated in these prescriptions, but there were prescriptions listing as many as 17 components.…”

Section: Níveis De Tsh Associados Ao Uso De Fórmulas Para Emagrecer Eunclassified

TSH levels associated with slimming pill use in a population-based study of brazilian women

Sichieri

Andrade

Baima

et al. 2007

Arq Bras Endocrinol Metab

View full text Add to dashboard Cite

Objective: To determine the consumption of slimming pills (SP) and its association with TSH levels. Research Methods and Procedures: A survey was carried out in Rio de Janeiro (about 5 million inhabitants), Brazil, from June 2004 to April 2005. Households (1,500) were selected using three-stage probability sampling. Women were asked about use of SP, and blood sample was collected. Women were classified as users of SP any time in life, but not in previous two months (n = 293), current users (n = 150), and never users (n = 853). Weighted multivariate regression analyses compared TSH levels among these groups of users. Results: The frequency of use of SP any time in life was 34% and the use in the previous two months was 11%. Both frequencies were greater among younger and obese women, and among those of high socioeconomic level (pvalue < 0.001). TSH level was statistically lower among current users of SP (1.96 mUI/ml; 95%CI = 1.93-1.98) compared to previous users 2.83 mUI/ml (95%CI = 2.13-3.02) and never users 2.59 mUI/ml (95%CI = 2.20-3.21). These differences were still statistically significant after adjusting for age and body mass index. Objetivo: Determinar a freqüência de uso de fórmulas para emagrecer e sua associação com níveis de TSH. Metodologia: Pesquisa realizada no Rio de Janeiro (5 milhões de habitantes), Brasil, de junho de 2004 a abril de 2005. A população de estudo foram mulheres com 35 anos ou mais, residentes em domicílios particulares permanentes do município do Rio de Janeiro não grávidas e não lactantes. A amostra de domicílios foi obtida por amostragem probabilística conglomerada em três estágios de seleção. As mulheres tiveram amostras de sangue coletadas e responderam a questões sobre uso de fórmulas, chás ou remédios para emagrecer. Quanto ao uso de fórmulas as mulheres foram classificadas em usuárias alguma vez na vida (n = 293), usuárias nos últimos dois meses (n = 150) e não usuárias (n = 853). Os níveis de TSH desses grupos foram comparados através de análise de regressão multivariada, levando em conta o desenho da amostra. Resultados: O uso de fórmulas alguma vez na vida foi relatado por 34% das mulheres e 11% relataram tê-las consumido nos últimos dois meses. As freqüências foram maiores entre as mulheres mais jovens e obesas e de nível sócio-econômico mais elevado (valor de p < 0,001). Os níveis de TSH foram estatisticamente menores entre as usuárias de fórmulas (1,96 mUI/ml; IC 95% = 1,93-1,98) comparados com usuárias prévias 2,83 mUI/ml (IC 95% = 2,13-3,02) e não usuárias 2,59 mUI/ml (IC 95% = 2,20-3,21). As diferenças entre os grupos mantiveram-se estatisticamente significantes após o ajuste por idade e índice de massa corporal. Conclusão: O uso de fórmulas para emagrecer diminuiu os níveis de TSH em mulheres brasileiras.

show abstract

“…The most common cause of TPP in thyrotoxicosis is Graves' disease, although TPP can occur with any form of thyrotoxicosis (1, 2). It is less commonly associated with thyroiditis (3, 4), toxic adenoma (5), T4 ingestion and iodine excess (6). However, very few cases such as this one have been reported as far as we know that thyrotoxic periodic paralysis associated with painless thyroiditis.…”

Section: Introductionmentioning

confidence: 99%

Thyrotoxic Periodic Paralysis Associated with Transient Thyrotoxicosis Due to Painless Thyroiditis

Ahn

et al. 2012

J Korean Med Sci

View full text Add to dashboard Cite

Thyrotoxic periodic paralysis (TPP) is a rare manifestation of hyperthyroidism characterized by muscle weakness and hypokalemia. All ethnicities can be affected, but TPP typically presents in men of Asian descent. The most common cause of TPP in thyrotoxicosis is Graves' disease. However, TPP can occur with any form of thyrotoxicosis. Up to our knowledge, very few cases ever reported the relationship between TPP and painless thyroiditis. We herein report a 25-yr-old Korean man who suffered from flaccid paralysis of the lower extremities and numbness of hands. The patient was subsequently diagnosed as having TPP associated with transient thyrotoxicosis due to painless thyroiditis. The paralytic attack did not recur after improving the thyroid function. Therefore, it is necessary that early diagnosis of TPP due to transient thyrotoxicosis is made to administer definite treatment and prevent recurrent paralysis.

show abstract

Thyrotoxic Periodic Paralysis in a Patient Abusing Thyroxine for Weight Reduction

Cited by 36 publications

References 5 publications

Toxicity of Weight Loss Agents

Toxicity of Weight Loss Agents

TSH levels associated with slimming pill use in a population-based study of brazilian women

Thyrotoxic Periodic Paralysis Associated with Transient Thyrotoxicosis Due to Painless Thyroiditis

Contact Info

Product

Resources

About