Thyrotoxic Periodic Paralysis - Are We Underestimating the Incidence

Manthri, Ranadheer Gupta

doi:10.18535/jmscr/v4i9.49

Cited by 2 publications

(4 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…TPP, a state in which proximal, symmetrical ascending muscle weakness in lower extremities occurs in hyperthyroid patients, is a multifactorial condition that involves hypokalemia and a hyperadrenergic state. [127] Pathogenesis still remains unclear, but it is known that a high amount of thyroid hormone present in the body leads to an increased activation and stimulation of channels and genes on the myocardium. Thyrotoxicosis leads to more binding and decreased inactivation of hormones at receptor sites located on tissues, commonly beta-2 adrenergic receptors on muscle cells.…”

Section: Discussionmentioning

confidence: 99%

“…It has been shown that with a new onset of hyperthyroidism that presents with paralytic attacks, it is rarely associated with the typical findings normally seen with hyperthyroidism. [17] In the patient presented, typical hyperthyroid symptoms such as palpitations, diarrhea, and heat intolerance were not evident, allowing TPP to be overlooked. Instead, muscle weakness and emesis were the first symptoms of a newly diagnosed hyperthyroidism.…”

Section: Discussionmentioning

confidence: 99%

“…Forty-four patients of 100 hyperthyroid patients that did not receive potassium supplementation presented with generalized muscle weakness and one patient died from ventricular arrhythmia with ECG changes consistent with hypokalemia. [7]…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

A rare case of hypokalemic ventricular tachycardia in a patient with thyrotoxic periodic paralysis

Ghalyoun

Khaddash

Shamoon

et al. 2019

Int J Crit Illn Inj Sci

View full text Add to dashboard Cite

Thyrotoxic periodic paralysis (TPP) is a potentially fatal complication of hyperthyroidism, characterized by recurrent muscle paralysis and hypokalemia. We present a case of a 32-year-old apparently healthy male patient, who presented with acute paraparesis associated with hypokalemia (K: 1.6 mmol/L), complicated by ventricular tachycardia (VT). Advanced cardiac life support was initiated with an amiodarone infusion, and eventually QRS complex narrowed and wide complex tachycardia resolved. Intravenous potassium chloride (KCl) 40 mEq over 2–3 h and oral KCL 40 mEq were administered to treat the electrolyte imbalance. Patient paralysis was quickly reversed; motor function was regained with movement of the lower extremities. This case highlights the importance of early recognition and prompt treatment of TPP as a differential diagnosis for muscle weakness, especially in the setting of severe hypokalemia. It is important to pay attention to the possibility of the development of lethal VT associated with hypokalemia in the setting of hyperthyroidism and thyrotoxic paralysis.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

A rare case of hypokalemic ventricular tachycardia in a patient with thyrotoxic periodic paralysis

Ghalyoun

Khaddash

Shamoon

et al. 2019

Int J Crit Illn Inj Sci

View full text Add to dashboard Cite

show abstract

“…However, these are found to be more common among patients with pre-existing cardiac diseases. According to one study by Manthri et al [16], in which they studied the incidence and prevention of TPP in patients of hyperthyroidism, 44 of 100 patients presented with muscle weakness and one of them died due to ventricular arrhythmia with ECG findings consistent with hypokalemia.…”

Section: Reviewmentioning

confidence: 99%