Thyrotoxic Auricular Fibrillation Treated with Thiouracil

Goodwin, J. F.

doi:10.1136/bmj.1.4611.895

Cited by 7 publications

(2 citation statements)

References 9 publications

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“…The relationship between arrhythmias and hyperthyroidism was noticed as early as the 1940s. The first studies showed that hyperthyroidism influences the incidence of sinus tachycardia, premature supraventricular beats, and atrial fibrillation [ 13 , 14 , 15 ]. A reduced TSH concentration is a risk factor for the occurrence of atrial fibrillation [ 11 ], and subclinical hyperthyroidism has also been shown to increase the risk of this arrhythmia [ 16 ].…”

Section: Discussionmentioning

confidence: 99%

Occurrence of Arrhythmias in Women with Thyroid Cancer Receiving Suppressive Doses of Levothyroxine

et al. 2021

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Aim of the study: To assess the occurrence of cardiac arrhythmias caused by high doses of levothyroxine in patients with thyroid cancer with subclinical hyperthyroidism. Materials and Methods: This prospective study included 98 women divided into three groups according to plasma thyroid stimulating hormone (TSH) concentration: <0.1 µU/mL, 0.1–0.39 µU/mL, or 0.4–4.0 µU/mL (control group). All participants underwent laboratory tests and an electrocardiography (ECG) Holter test to assess their heart rate and the occurrence of arrhythmias. Statistical analysis assessed differences between groups in all clinical parameters and factors influencing the occurrence of arrhythmias. Results: There were no differences between groups in the maximum, average, or minimum heart rate or in the incidence of the studied cardiac arrhythmias. Heart rate in women with a TSH concentration of <0.1 µU/mL depended on age and the presence of arterial hypertension, and heart rate in women with a TSH concentration of 0.4–4.0 µU/mL depended on free triiodothyronine concentration and the presence of arterial hypertension; no relationship was identified for women with a TSH concentration of 0.1–0.39 µU/mL. One-way logistic regression analysis did not identify any factors influencing the occurrence of arrhythmias. Conclusions: While maintaining normal free triiodothyronine levels, the use of suppressive doses of levothyroxine after thyroidectomy for differentiated thyroid cancer does not induce clinically significant arrhythmias or affect average heart rate. None of the studied clinical parameters influenced the risk of arrhythmia.

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Section: Discussionmentioning

confidence: 99%

Occurrence of Arrhythmias in Women with Thyroid Cancer Receiving Suppressive Doses of Levothyroxine

et al. 2021

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“…The Antithyroid Agents and Thyrotoxic Fibrillation.-In one-third to one-half of cases of auricular fibrillation of thyrotoxic origin, the heart reverts spontaneously to normal rhythm following the administration of thiouracil or its derivatives only. The return of normal rhythm was reported in 12 out of 18 cases (67 per cent) by McGarack, Gerl, Morton, Vogel, and Schwimmer (1945) ; in 8 out of 16 cases (50 per cent) by Cookson and Staines (1947) ; in 8 out of 15 (53 per cent) by Murray (1950) ; in 4 out of 10 (40 per cent) by Verel (1949) ; in 12 out of 28 cases (43 per cent) by Goodwin (1949) ; and in 9 out of 23 cases (39 per cent) by Douglas and Kennie (1952). Return to normal rhythm may infrequently be associated with peripheral embolism and 4 such experiences are reported by Aird (1949).…”

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confidence: 97%