Thyroperoxidase and Thyroglobulin Antibodies in Early Pregnancy and Preterm Delivery

Haddow, James E.; Cleary-Goldman, Jane; McClain, Monica R.; Palomaki, Glenn E.; Neveux, Louis M.; Lambert‐Messerlian, Geralyn; Canick, Jacob A.; Malone, FD; Porter, T. Flint; Nyberg, David A.; Bernstein, Peter S.; D'Alton, ME

doi:10.1097/01.aoa.0000400327.72582.55

Cited by 11 publications

(9 citation statements)

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“…[26][27][28] Only 1 small study has evaluated role of intervention with levothyroxine in TPO positive euthyroid pregnant women. However, this association has not been confirmed in several larger trials.…”

Section: Preterm Birthmentioning

confidence: 99%

Thyroid Autoantibodies and Pregnancy Outcomes

Abbassi-Ghanavati

2011

Clinical Obstetrics &Amp; Gynecology

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Autoimmune thyroid disease has been associated with several adverse pregnancy outcomes. Increased risk of spontaneous miscarriage and placental abruption in women with thyroid antibodies has been confirmed in multiple studies. However, benefit of intervention and treatment of autoimmune thyroid disease in otherwise euthyroid pregnant women has not been sufficiently studied. The data on the association of thyroid antibodies and recurrent pregnancy loss or preterm birth are conflicting and a statistically significant association has not been shown in large studies. At present time, routine screening and treatment of autoimmune thyroid disease in euthyroid pregnant women is not warranted.

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Section: Preterm Birthmentioning

confidence: 99%

Thyroid Autoantibodies and Pregnancy Outcomes

Abbassi-Ghanavati

2011

Clinical Obstetrics &Amp; Gynecology

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“…Their results were similar to those published by us previously, 2 and to recent reports. 5 The current study showed that 6% of both thyroid peroxidase antibody-positive and thyroid peroxidase antibody-negative mothers had preterm births (before or at 36 weeks). 2 Similarly, a nonsignificant association was found in the FASTER trial, with 7.5% and 6.4% of thyroid peroxidase antibody-positive and thyroid peroxidase antibody-negative mothers, respectively, having preterm birth.…”

Section: To the Editormentioning

confidence: 50%

“…5 We found that 5.9% and 4.9% of thyroid peroxidase antibody-positive and thyroid peroxidase antibody-negative mothers, respectively, had preterm birth before 37 weeks of gestation (difference not significant). Their results were similar to those published by us previously, 2 and to recent reports.…”

Section: To the Editormentioning

confidence: 61%

Pregnancy Outcomes in Women With Thyroid Peroxidase Antibodies

Männistö

Vääräsmäki²,

Suvanto³

2011

Obstetrics &Amp; Gynecology

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“…We focused on the antenatal detection of autoimmune thyroid disease because of growing evidence that the presence of TPOAb is associated with adverse obstetric and postnatal outcomes. Associations have been noted between TPOAb positivity and miscarriage, preterm delivery, preterm premature rupture of membranes, placental abruption, foetal death, postpartum thyroiditis, postpartum thyroid dysfunction, neonatal hyperbilirubinaemia, sensorineural hearing loss, behavioural problems in children and impaired development in the offspring . However, at this time, there are only a few intervention trials evaluating the effect of levothyroxine treatment on obstetrical complication rates in pregnant women with euthyroid thyroiditis or subclinical hypothyroidism.…”

Section: Discussionmentioning

confidence: 99%